Microarchitecture, Bone Strength and Fracture Risk in Long-term Type 1 Diabetes
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Type 1 Diabetes Mellitus
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: N/AIntervention Model: Single Group AssignmentIntervention Model Description: Identical diagnostic procedures will be performed in participants with type 1 diabetes and age- and sex-matched controls.Masking: None (Open Label)Primary Purpose: Diagnostic
Participation Requirements
- Age
- Between 40 years and 80 years
- Gender
- Both males and females
Description
Based on a cross-sectional approach the investigators aim to assess microstructural, biomechanical and densitometric bone characteristics in patients with longstanding type 1 diabetes and age- and sex-matches controls. The investigators examine whether the presence of microvascular disease and/or po...
Based on a cross-sectional approach the investigators aim to assess microstructural, biomechanical and densitometric bone characteristics in patients with longstanding type 1 diabetes and age- and sex-matches controls. The investigators examine whether the presence of microvascular disease and/or poor diabetic control is associated with an altered bone microarchitecture and whether any such effect is independent of bone mineral density. Furthermore, the investigators aim to look into the relationship between an altered bone microarchitecture and advanced glycation end product (AGE) formation as well as biochemical markers of bone formation and bone turnover. The study aims to identify type 1 diabetic patients with high fracture risk by assessing the discriminatory power of parameters of cortical and trabecular microstructure measured via high resolution peripheral quantitative computed tomography (HR-pQCT) of the distal radius and tibia and high resolution quantitative computed tomography (HR-QCT) of the proximal femur and tibia with and without adjustment for bone density.
Tracking Information
- NCT #
- NCT03751839
- Collaborators
- University Hospital Inselspital, Berne
- University Hospital Schleswig-Holstein
- University Hospital, Basel, Switzerland
- Investigators
- Principal Investigator: Christian Meier, Prof. University Hospital, Basel, Switzerland