Altered Connections in the Spinal Cord to Reduce Hand Impairment After Stroke
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Central Nervous System Haemorrhage
- Cerebrovascular Accident
- Post Stroke
- Stroke
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: Non-RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: The purpose of the study is to induce plasticity in corticospinal-motoneuronal synapses serving an intrinsic hand muscle of the hemiparetic limb in humans with stroke. Neurologically-intact controls are included to verify that an effect was present in absence of strokeMasking: None (Open Label)Primary Purpose: Basic Science
Participation Requirements
- Age
- Between 18 years and 75 years
- Gender
- Both males and females
Description
Stroke is a leading cause of serious long-term disability in the United States with 795,000 individuals suffering a new or recurrent stroke each year. In most cases, disability is associated with incomplete motor recovery of the paretic limb. Even with intensive therapy, full recovery is often not a...
Stroke is a leading cause of serious long-term disability in the United States with 795,000 individuals suffering a new or recurrent stroke each year. In most cases, disability is associated with incomplete motor recovery of the paretic limb. Even with intensive therapy, full recovery is often not achieved. Thus, there is a need for mechanistic approaches that drive the impaired neuronal targets of retraining to fully harness the corticospinal system's adaptive capacity. This study will attempt to induce bi-directional STDP in corticospinal-motoneuronal synapses serving an intrinsic hand muscle of the hemiparetic limb. Control experiments will be completed to provide evidence of the neurophysiological mechanism(s) mediating the effect and to examine behavioral effects. Individuals who are at least 6 months post first-ever subcortical stroke and have at least partial range of motion of the paretic index finger will be invited to participate.
Tracking Information
- NCT #
- NCT03645122
- Collaborators
- University of Pittsburgh
- Investigators
- Principal Investigator: Michael A. Urbin, PhD VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
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