North American Prodromal Synucleinopathy Consortium
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- 300
Summary
- Conditions
- Dementia With Lewy Bodies
- Lewy Body Disease
- Multiple System Atrophy
- Parkinson Disease
- REM Sleep Behavior Disorder
- REM Sleep Parasomnias
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
REM sleep behavior disorder (RBD) is a rare disorder where people act out their dreams. People with RBD often, but not always, develop Parkinson's Disease, dementia with Lewy bodies, multiple system atrophy, or other neurodegenerative diseases of the synucleinopathy type. The North American Prodroma...
REM sleep behavior disorder (RBD) is a rare disorder where people act out their dreams. People with RBD often, but not always, develop Parkinson's Disease, dementia with Lewy bodies, multiple system atrophy, or other neurodegenerative diseases of the synucleinopathy type. The North American Prodromal Synucleinopathy (NAPS) Consortium was formed with the purpose of enrolling participants with RBD, in anticipation of a future clinical trial of a neuroprotective treatment against synucleinopathies. The NAPS Consortium will collect standardized clinical assessments, biofluids, and other data in order to develop biomarkers for synucleinopathies in the prodromal (presymptomatic) stage as well as a trial-ready registry of participants. Participants procedures will include a ~2-hour clinical assessment (medical history and physical exam), questionnaires, blood draw, and (at select sites) optional lumbar puncture.
Tracking Information
- NCT #
- NCT03623672
- Collaborators
- Mayo Clinic
- University of Minnesota
- University of California, Los Angeles
- McGill University
- Emory University
- Massachusetts General Hospital
- National Institute on Aging (NIA)
- Stanford University
- Banner Health
- Portland VA Medical Center
- Investigators
- Principal Investigator: Yo-El Ju, MD Washington University School of Medicine Principal Investigator: Bradley Boeve, MD Mayo Clinic