Recruitment

Recruitment Status
Recruiting
Estimated Enrollment
1000

Summary

Conditions
  • Acute Respiratory Distress Syndrome
  • Conventional Mechanical Ventilation
  • High Frequency Oscillation Ventilation
Type
Interventional
Phase
Not Applicable
Design
Allocation: RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: When the neonate had fulfilled the included criteria, selective HFOV or CMV were started immediately on the basis of the group assignment.Masking: Triple (Participant, Investigator, Outcomes Assessor)Primary Purpose: Treatment

Participation Requirements

Age
Younger than 12 years
Gender
Both males and females

Description

Severe acute respiratory distress syndrome (ARDS) is one of the serious complications in critically ill neonates. It can result in severe hypoxemia refractory to mechanical ventilation. Usually, invasive ventilation with low parameters is enough for neonates with mild and moderate ARDS. And extracor...

Severe acute respiratory distress syndrome (ARDS) is one of the serious complications in critically ill neonates. It can result in severe hypoxemia refractory to mechanical ventilation. Usually, invasive ventilation with low parameters is enough for neonates with mild and moderate ARDS. And extracorporeal membrane oxygenation is used to neonates with severe ARDS. However, extracorporeal membrane oxygenation can also lead to high death rate and need more technique and conditions. Mechanical ventilation with higher parameters was a substitute for such situations, but the death rate, complications and injuries of higher parameters is unknown. The purpose of the present study was to compare HFOV with CMV as invasive respiratory support strategies on decrease the mortality and morbidities in neonate with ARDS.

Tracking Information

NCT #
NCT03591796
Collaborators
  • Chongqing Maternal and Child Health Hospital
  • Children's Hospital of Chongqing Medical University
  • Women's Hospital School Of Medicine Zhejiang University
  • Jiulongpo No.1 People's Hospital
  • Xuzhou Children Hospital
  • Zhujiang Hospital
  • First Affiliated Hospital of Guangxi Medical University
  • Mianyang Central Hospital
  • The First Affiliated Hospital of Anhui Medical University
  • Shanghai Children's Medical Center
  • Women and Children's Health Hospital of Yulin
  • Shanxi Provincial Maternity and Children's Hospital
  • Beijing 302 Hospital
  • Xianyang children's Hospital
  • The Affiliated Hospital Of Southwest Medical University
  • The First Hospital of Jilin University
  • Yan'an Affiliated Hospital of Kunming Medical University
  • The Children's Hospital of Zhejiang University School of Medicine
  • Jiangxi Province Children's Hospital
  • Inner Mongolia People's Hospital
  • Shenzhen People's Hospital, The Second Medical College of Jinan University
  • LanZhou University
  • Children's Hospital of The Capital Institute of Pediatrics
  • Guangdong Women and Children Hospital
  • Third Affiliated Hospital of Zhengzhou University
  • The Second Hospital of Shandong University
  • People's Hospital of Xinjiang Uygur Autonomous Region
  • the Maternal and Child Health Hospital of Hainan Province
  • Women and Children's Health Hospital of Qujing
  • Maternal and Children's Healthcare Hospital of Taian
  • Zunyi First People's Hospital
  • The First Affiliated Hospital of Zhengzhou University
  • Guangdong Academy of Medical Science and General Hospital
  • Women and Children Hospital of Qinghai Province
  • The First People's Hospital of Yunnan
  • Wuhan Union Hospital, China
  • Tianjin Central Hospital of Gynecology Obstetrics
  • Nanjing Medical University
  • Women and Children Health Care Hospitalof GuangXi Zhuang Autonomous
  • Children's Hospital of Fudan University
  • Second Hospital of Lanzhou University
  • Peking University Third Hospital
  • First Hospital of Tsinghua University
  • First Affiliated Hospital of Harbin Medical University
  • Chengdu Women and Children's Center Hospital
  • First Affiliated Hospital of Xinjiang Medical University
  • Ningbo Women & Children's Hospital
  • Affiliated Hospital of Southwest Medical University
  • Gansu Provincial Maternity and Child-Care Hospital
  • People's Liberation Army No.202 Hospital
  • Zhengzhou Children's Hospital, China
  • Bethune International Peace Hospital
  • Women and Children's Hospital, Branch of Chongqing Sanxia Central Hospital
  • First Affiliated Hospital of Chongqing Medical University
  • Quanzhou Children's Hospital
  • Xiamen Maternity & Child Care Hospital
  • The First Affiliated Hospital of Kunming Medical College
  • The People's Hospital of Dehong Autonomous Prefecture
  • Second Affiliated Hospital of Guangzhou Medical University
  • Guiyang Maternal and Child Health Care Hospital
  • Kunming Children's Hospital
  • Children's Hospital of Nanjing Medical University
  • Hunan Children's Hospital
  • Qinhuangdao Maternal and Child Health Care Hospital
  • Yinchuan No 1 people's Hospital Affiliated of Ningxia Medical University
Investigators
Not Provided