Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- 22
Summary
- Conditions
- Insulin Sensitivity
- Vascular Stiffness
- Type
- Interventional
- Phase
- Early Phase 1
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentIntervention Model Description: Each subject is studied 4 times in a randomized sequential orderMasking: None (Open Label)Primary Purpose: Basic Science
Participation Requirements
- Age
- Between 18 years and 35 years
- Gender
- Both males and females
Description
The investigators will study 22 healthy subjects (18-35 yrs) four times as follows: Saline + Octreotide + euglycemia; Octreotide + hyperglycemia; Octreotide + hyperglycemia + insulin clamp and Octreotide + Euglycemia + insulin clamp. The sequence of admissions will be assigned randomly. The investig...
The investigators will study 22 healthy subjects (18-35 yrs) four times as follows: Saline + Octreotide + euglycemia; Octreotide + hyperglycemia; Octreotide + hyperglycemia + insulin clamp and Octreotide + Euglycemia + insulin clamp. The sequence of admissions will be assigned randomly. The investigators will assess function in conduit (pulse wave velocity-PWV, augmentation index-AI and flow-mediated dilation-FMD), resistance (post-ischemic flow velocity-PIFV) and heart and skeletal muscle microvascular (contrast enhanced ultrasound-CEU) vessels. This work will: a) identify whether vascular stiffness and indices of NO action are impaired throughout the arterial tree with hyperglycemia.
Tracking Information
- NCT #
- NCT03520569
- Collaborators
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Investigators
- Not Provided
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