PG and PK of Oxycodone to Personalize Post-op Pain Management Following Surgery in Children

Summary

Participation Requirements

Description

Research procedures will include: Pre-operative blood draw for genotyping candidate genes and exploratory genes and for future similar studies will be collected. Standardized pre-, intra-, and post-operative care will be received by all participants. The study team will record medical history, demog...

Research procedures will include: Pre-operative blood draw for genotyping candidate genes and exploratory genes and for future similar studies will be collected. Standardized pre-, intra-, and post-operative care will be received by all participants. The study team will record medical history, demographic information, concomitant medications, vitals, pain scores, post-operative nausea and vomiting, and all medications given post-surgery for pain management throughout the participants in-patient stay. Psychological questionnaires to assess pain, risk of developing OD and chronic pain, anxiety and depression will be administered pre-operatively, and 48-72 hours, 7-14 days, 2 months, 3 months, 6 months and 12 months post-operatively. Quantitative Sensory Testing will be performed on up to 100 participants pre-operatively, and 48-72 hours,3 months and 12 months post-operatively. Serial blood draws for oxycodone and methadone pharmacokinetic modeling will be collected from up to 200 participants. QTc measurements will also be recorded from pre- and post-operative EKGs for those participants in which methadone pharmacokinetic blood samples are collected.

Tracking Information