Acute Kidney Injury After Cardiac Surgery
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- 400
Summary
- Conditions
- Acute Kidney Injury
- Type
- Observational
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Although acute kidney injury (AKI) frequently complicates cardiac surgery, methods to determine AKI risk in patients without underlying kidney disease are lacking. Renal functional reserve (RFR) can be used to measure the capacity of the kidney to increase glomerular filtration rate under conditions...
Although acute kidney injury (AKI) frequently complicates cardiac surgery, methods to determine AKI risk in patients without underlying kidney disease are lacking. Renal functional reserve (RFR) can be used to measure the capacity of the kidney to increase glomerular filtration rate under conditions of physiological stress and may serve as a functional marker that assesses susceptibility to injury. The investigators seek to determine whether a reduced preoperative RFR predicts postoperative AKI in patients with normal estimated glomerular filtration rates undergoing elective cardiac surgery. All centres will measure RFR with creatinine clearance, except University Hospital Giessen where in addition iohexol plasma-clearance will be used.
Tracking Information
- NCT #
- NCT03457987
- Collaborators
- Guy's and St Thomas' NHS Foundation Trust
- Shanghai Jiao Tong University School of Medicine
- Robert Bosch Medical Center
- Ospedale San Bortolo di Vicenza
- Azienda Ospedaliero Universitaria Maggiore della Carita
- Charite University, Berlin, Germany
- Investigators
- Study Director: Claudio Ronco, MD San Bortolo Hospital, Vicenza, Italy