Ketogenic Diet for Reduction of CNS Oxygen Toxicity in Working Divers
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- CNS Oxygen Toxicity, Ketogenic Diet
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: RandomizedIntervention Model: Crossover AssignmentIntervention Model Description: Each subject will randomize to one of two arms and will crossover to the other arm at least one week later.Masking: Double (Investigator, Outcomes Assessor)Masking Description: Neither the investigator nor the outcomes assessor will no the ketone level of the participant during either arm of the studyPrimary Purpose: Prevention
Participation Requirements
- Age
- Between 18 years and 50 years
- Gender
- Both males and females
Description
Participants in the study will undergo a physical exam and testing as well as training on cognitive testing software as part of the screening process. Eligible subjects will be assigned a normal diet or a ketogenic diet (a diet high in fat/protein and low in carbohydrates) for three days before test...
Participants in the study will undergo a physical exam and testing as well as training on cognitive testing software as part of the screening process. Eligible subjects will be assigned a normal diet or a ketogenic diet (a diet high in fat/protein and low in carbohydrates) for three days before testing. Subjects will be immersed in water to the shoulders, inside a hyperbaric (high pressure) chamber while breathing 100% oxygen at increased atmospheric pressure, and doing cycling exercise. Testing on the cognitive software, as well as blood sampling and physical monitoring will be done while in the chamber. All tests and procedures will be completed again at least one week later with the diet not assigned for the first session.
Tracking Information
- NCT #
- NCT03433261
- Collaborators
- United States Department of Defense
- Investigators
- Not Provided
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