Efficacy of HIPEC in the Treatment of Advanced-Stage Epithelial Ovarian Cancer After Cytoreductive Surgery
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- 214
Summary
- Conditions
- Epithelial Ovarian Cancer
- Fallopian Tube Cancer
- Primary Peritoneal Carcinoma
- Type
- Interventional
- Phase
- Phase 3
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentMasking: None (Open Label)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 70 years
- Gender
- Only males
Description
The current standard treatment for epithelial ovarian cancer, tubal cancer, and primary peritoneal cancer is maximal cytoreductive surgery followed by intravenous chemotherapy with or without intraperitoneal chemotherapy (IP). Recently, the organizations of SGO and ASCO recommended that women with F...
The current standard treatment for epithelial ovarian cancer, tubal cancer, and primary peritoneal cancer is maximal cytoreductive surgery followed by intravenous chemotherapy with or without intraperitoneal chemotherapy (IP). Recently, the organizations of SGO and ASCO recommended that women with Fagotti score by laparoscopic exploration < 6 would benefit from primary cytoreductive surgery followed by postoperative chemotherapy, and are likely to attain optimal cytoreduction (residual lesion ? 1 cm). Hyperthermia promotes chemotherapy to penetrate deeper into the cancer tissue. Therefore, hyperthermic intraperitoneal chemotherapy (HIPEC) as newly postoperative chemotherapy after primary cytoreductive surgery in the treatment of ovarian cancer could lead to higher response rate and better survival outcomes.
Tracking Information
- NCT #
- NCT03373058
- Collaborators
- The Third Xiangya Hospital of Central South University
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Third Affiliated Hospital, Sun Yat-Sen University
- West China Second University Hospital
- First Affiliated Hospital of Chongqing Medical University
- Wuhan University
- Beijing Obstetrics and Gynecology Hospital
- Southern Medical University, China
- Henan Provincial People's Hospital
- Xiangya Hospital of Central South University
- Fourth Affiliated Hospital of Guangxi Medical University
- Xinqiao Hospital of Chongqing
- Wuhan Union Hospital, China
- Henan Cancer Hospital
- Beijing Cancer Hospital
- Peking University People's Hospital
- Tianjin Medical University Cancer Institute and Hospital
- Chongqing University Cancer Hospital
- Cancer Hospital of Guizhou Province
- Cancer Hospital of Shantou University
- The Third Affiliated Hospital of Guangzhou Medical University
- Shandong Cancer Hospital and Institute
- Chinese PLA General Hospital
- Hebei Medical University Fourth Hospital
- RenJi Hospital
- Peking Union Medical College Hospital
- First Affiliated Hospital, Sun Yat-Sen University
- Obstetrics & Gynecology Hospital of Fudan University
- The Second Hospital of Hebei Medical University
- Investigators
- Study Director: Shuzhong Cui, M.D Affiliated Cancer Hospital & Institute of Guangzhou Medical University Study Director: Zhongqiu Lin, M.D Sun Yat-sen Memorial Hospital,Sun Yat-sen University
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