Modeling Bronchial Epithelium Modifications Associated With COPD Using iPS
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Pulmonary Disease, Chronic Obstructive
- Smoking
- Type
- Observational
- Design
- Observational Model: OtherTime Perspective: Cross-Sectional
Participation Requirements
- Age
- Between 18 years and 55 years
- Gender
- Both males and females
Description
Secondary objectives: Confrontation of the two models of in vitro generation of bronchial epithelium by iPS and ALI in order to validate our model of study of the human bronchial epithelium COPD generated by the iPS. Inducing a "COPD-like" epithelial phenotype by exposing the bronchial epithelia gen...
Secondary objectives: Confrontation of the two models of in vitro generation of bronchial epithelium by iPS and ALI in order to validate our model of study of the human bronchial epithelium COPD generated by the iPS. Inducing a "COPD-like" epithelial phenotype by exposing the bronchial epithelia generated from the iPS to a source of in vitro toxin (tobacco) and studying its effects by transcriptomic analysis via high-throughput sequencing (NGS) at key steps during the model. Demonstrate the feasibility of obtaining iPS from peripheral blood sampling.
Tracking Information
- NCT #
- NCT03181204
- Collaborators
- Not Provided
- Investigators
- Study Director: Arnaud Bourdin, MD, PhD University Hospital, Montpellier
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