The Evaluation of Endothelial Function in the Diagnosis of Acute Coronary Syndrome (ACS)

Summary

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Description

Chest pain is a frequent reason for consultation in the emergency room, which can be as much as 5 to 10% of consultants. Problems in etiologic diagnosis are often encountered due to the variety of etiologies of chest pain. Among them is the acute coronary syndrome, which is a major cause of mortalit...

Chest pain is a frequent reason for consultation in the emergency room, which can be as much as 5 to 10% of consultants. Problems in etiologic diagnosis are often encountered due to the variety of etiologies of chest pain. Among them is the acute coronary syndrome, which is a major cause of mortality and morbidity. The endothelium plays a crucial role in maintaining the tone and vascular integrity and in particular the secretion of vasodilator and vasoconstrictor mediators. In most vascular pathologies, this equilibrium will be broken by the attenuation of the vasodilating function of the endothelium. This is called endothelial dysfunction. Several tools for measuring endothelial function have been developed, the main characteristics of which are: noninvasive, reproducible, independent operators, predictive of the disease, safe for subjects, inexpensive and easy to use. In this study we will be interested in digital plethysmography which has shown its effectiveness in: Screening for cardiovascular risk in asymptomatic subjects. The risk of a new cardiovascular event in the sick. Evaluation of the response to certain therapies. Goal of the study : The objective of this study is to verify the contribution of digital plethysmography in the early diagnosis of acute coronary syndrome in emergency departments. To determine the sensitivity, specificity, negative and positive predictive value of this method that was not previously used for this purpose, hence the originality of this study.

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