The Use of Decitabine as Induction Therapy for Acute Myeloid Leukemia With Complex and/or Monosomal Karyotype

Summary

Participation Requirements

Description

This is an open-label interventional study to study the use of decitabine as induction therapy for acute myeloid leukemia with complex and/or monosomal karyotype. Subjects will receive decitabine for every 28 days, until disease progression or a bone marrow transplantation is carried out, in the sch...

This is an open-label interventional study to study the use of decitabine as induction therapy for acute myeloid leukemia with complex and/or monosomal karyotype. Subjects will receive decitabine for every 28 days, until disease progression or a bone marrow transplantation is carried out, in the schedule as below: Cycle 1: Receive decitabine for 10 days Cycle 2 and Cycle 3: Based on the result of bone marrow examination, subjects may receive decitabine for 5 days or 10 days Cycle 4 until disease progression: Rdecitabine for 5 days. Subjects may also resume a 10 day treatment after cycle 6 if their physician judged as appropriate. The drug will then be administrated intravenously. Blood will be drawn every 7 days and bone marrow extraction would be done on Day 28 (+/- 3days) from the day 1 of each cycle of treatment for examination.

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