Shanghai High Myopia Study
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Cataract
- Genetic Anticipation
- High Myopia
- Visual Outcome
- Design
- Observational Model: OtherTime Perspective: Prospective
Participation Requirements
- Age
- Between 20 years and 100 years
- Gender
- Both males and females
Description
High myopic cataract (HMC) has become a major high-risky type of cataract in China, which accounts for nearly 30% of cataract in recent years. Compared to age-related cataract, HMC is characterized with earlier onset, severer lens opacities, higher incidence of vitreoretinopathy and postoperative co...
High myopic cataract (HMC) has become a major high-risky type of cataract in China, which accounts for nearly 30% of cataract in recent years. Compared to age-related cataract, HMC is characterized with earlier onset, severer lens opacities, higher incidence of vitreoretinopathy and postoperative complications compared to age-related cataract(ARC). The main purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of high myopic cataract, when compared to those age-matched ARC patients. On the other hand, due to the lack of research in the pathogenesis of HMC, it is difficult for the investigators to precisely evaluate its risk and prognosis, and to improve its prevention and treatment. The previous study of investigators majored in a large-sample analysis on the clinical features and related genes of HMC. After preliminary screening, eight genes were selected for further investigation: 1) genes related to pathogenesis of HMC: CRYAA/ GSTP1/ TXNRD2;2) genes related to vitreoretinopathy: MCP1/ VEGFA/ CFH; 3) genes related to postoperative complications: TGFB2/ CERS2. In the present study, in order to establish a risk model of HMC from the aspect of precision medicine, the investigators are preparing to set up a comprehensive clinical database for further sequencing of selected genes (including exons, promoters, 5' UTR and 3' UTR sequences) on a large scale, to intensively investigate into the sites and functions of single nucleotide polymorphism (SNP) correlated with clinical features of HMC. The research aim to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of high myopic cataract, to thoroughly illustrate the influence of HMC-related genes to its prognosis and to elucidate the pathogenesis of HMC, for further promotion in the disease prevention and prognosis as well.
Tracking Information
- NCT #
- NCT03062085
- Collaborators
- Eye & ENT Hospital of Fudan University
- Investigators
- Study Chair: Yi Lu, M.D. Eye and ENT Hospital of Fudan University Study Director: Xiangjia Zhu, M.D. Eye and ENT Hospital of Fudan University Principal Investigator: Keke Zhang, M.D. Eye and ENT Hospital of Fudan University Principal Investigator: Wenwen He, M.D. Eye and ENT Hospital of Fudan University Principal Investigator: Yu Du, B.S. Eye and ENT Hospital of Fudan University Principal Investigator: Yinglei Zhang, M.D. Eye and ENT Hospital of Fudan University Principal Investigator: Zhennan Zhao, Ph.D. Eye and ENT Hospital of Fudan University Principal Investigator: Ruiqi Chang, B.S. Eye and ENT Hospital of Fudan University