Diagnosis of Tuberculosis in Swiss Children

Summary

Participation Requirements

Description

This will be done by measuring a variety of parameters in the blood samples and compare them with the current diagnostic gold standard for TB or for culture/NAAT non-confirmed TB cases a consensus case definition is used. Currently available immunodiagnostic tests (IGRA/TST) will be compared to nove...

This will be done by measuring a variety of parameters in the blood samples and compare them with the current diagnostic gold standard for TB or for culture/NAAT non-confirmed TB cases a consensus case definition is used. Currently available immunodiagnostic tests (IGRA/TST) will be compared to novel immunodiagnostic tests which will include: several novel, additional M. tuberculosis-specific Antigens cytokines that are highly expressed Since there is no diagnostic gold standard for TB infection we will rely on a clinical composite reference standard for diagnosing TB infection. Biomarkers will be determined by: including M. tuberculosis-specific antigens that are specifically expressed in either TB infection or disease, measuring phenotypes and cytokine production of M. tuberculosis-specific cells.

Tracking Information