Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- 1200
Summary
- Conditions
- Analgesia
- Dexmedetomidine
- Elderly
- Long Term Outcome
- Surgery
- Type
- Interventional
- Phase
- Phase 4
- Design
- Allocation: RandomizedIntervention Model: Parallel AssignmentMasking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)Primary Purpose: Prevention
Participation Requirements
- Age
- Between 65 years and 90 years
- Gender
- Both males and females
Description
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen the quality of life and shorten the duration of survival. Perioperative immune function is a key element that influences postoperati...
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen the quality of life and shorten the duration of survival. Perioperative immune function is a key element that influences postoperative tumor recurrence and metastasis; but it is subject to the impacts of many factors. Studies showed that elevated cortisol level and inflammation provoked by surgical stress result in suppression of immune function, whereas dexmedetomidine alleviates the elevated cortisol level and inhibit excessive inflammation; high-dose opioids inhibit the immune function and increase the invasiveness of tumor cells, whereas dexmedetomidine reduces the consumption of opioids during perioperative period; postoperative sleep disturbances also impair immune function, whereas dexmedetomidine improves sleep quality in patients after surgery; occurrence of postoperative delirium is associated with increased mortality, whereas dexmedetomidine reduces delirium incidence. The investigators hypothesize that dexmedetomidine supplemented analgesia in elderly patients after cancer surgery may improve the long-term outcomes, possibly by relieving stress and inflammatory response, improving analgesic efficacy and sleep quality, and reducing delirium incidence.
Tracking Information
- NCT #
- NCT03012971
- Collaborators
- The Second Affiliated Hospital of Air Force Medical University
- Affiliated Hospital of Hebei University
- Qingdao Municipal Hospital
- Beijing Chao Yang Hospital
- Beijing Shijitan Hospital, Capital Medical University
- Beijing Tsinghua Chang Gung Hospital
- Peking University International Hospital
- Beijing Ditan Hospital
- Guizhou Provincial People's Hospital
- Tianjin Hospital of ITCWM-Nankai Hospital
- The Third Xiangya Hospital of Central South University
- Shanxi Provincial Cancer Hospital
- Zhongda Hospital Southeast University
- Investigators
- Principal Investigator: Dong-Xin Wang, MD, PhD Peking University First Hospital