Impact of ART Adherence on HIV Persistence and Inflammation
Last updated on July 2021Recruitment
- Recruitment Status
- Active, not recruiting
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Human Immunodeficiency Virus
- Design
- Observational Model: Ecologic or CommunityTime Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Understanding whether the size and dynamics of the HIV reservoir are associated with adherence, measured by an objective biomarker, could have significant clinical and therapeutic implications for ART and HIV cure. First, this aim will quantify levels of CA-RNA, CA-DNA, and plasma residual viremia i...
Understanding whether the size and dynamics of the HIV reservoir are associated with adherence, measured by an objective biomarker, could have significant clinical and therapeutic implications for ART and HIV cure. First, this aim will quantify levels of CA-RNA, CA-DNA, and plasma residual viremia in suppressed, HIV infected individuals and correlate them with levels of TFV-DP in DBS as a measure of cumulate drug exposure (adherence). Second, this study will evaluate the changes in the HIV reservoir in relation to changes in ART adherence over time.
Tracking Information
- NCT #
- NCT02797093
- Collaborators
- National Institute of Allergy and Infectious Diseases (NIAID)
- Investigators
- Principal Investigator: Jose R Castillo-Mancilla, MD University of Colorado, Denver
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