Open Lung Strategy in Critically Ill Morbid Obese Patients
Last updated on July 2021Recruitment
- Recruitment Status
- Active, not recruiting
- Estimated Enrollment
- 12
Summary
- Conditions
- Obesity
- Pulmonary Atelectasis
- Respiratory Insufficiency
- Respiratory Mechanics
- Right-Sided Heart Failure
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: Non-RandomizedIntervention Model: Crossover AssignmentIntervention Model Description: Physiologic crossover study. There is no randomization. All participants will receive the same interventions in the same order.Masking: None (Open Label)Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Obese patients under mechanical ventilation are more likely to develop atelectasis as a consequence of the increased abdominal weight. Atelectasis is the primary responsible for respiratory insufficiency and impossibility to wean obese patients from respiratory support. In a previous study we demons...
Obese patients under mechanical ventilation are more likely to develop atelectasis as a consequence of the increased abdominal weight. Atelectasis is the primary responsible for respiratory insufficiency and impossibility to wean obese patients from respiratory support. In a previous study we demonstrated the efficacy of the application of titrated PEEP levels following a recruitment maneuver in obese patients, i.e. improvement in respiratory mechanics and gas exchanges without negative hemodynamic effects. The application of lung and heat imaging will allow us to quantitatively describe: Increase in aerated lung tissue (reduction of atelectasis) Reduction of over-inflation of the ventilated regions Recoupling of ventilation and perfusion Improvement in right heart function by reduction of right heart afterload
Tracking Information
- NCT #
- NCT02503241
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Robert Kacmarek, RRT, PhD Massachusetts General Hospital Principal Investigator: Lorenzo Berra, MD Massachusetts General Hospital
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