Gluten Challenge in Celiac Disease
Last updated on July 2021Recruitment
- Recruitment Status
- Recruiting
- Estimated Enrollment
- 86
Summary
- Conditions
- Celiac Disease
- Type
- Interventional
- Phase
- Not Applicable
- Design
- Allocation: N/AIntervention Model: Single Group AssignmentMasking: None (Open Label)Primary Purpose: Basic Science
Participation Requirements
- Age
- Between 18 years and 80 years
- Gender
- Both males and females
Description
Before and 6 days after start of gluten challenge, blood samples will be collected and analysed by using HLA-tetramers to identify and purify CD4+ gluten-specific T cells by flow cytometry. T cells will undergo transcriptome analysis to get an insight in signalling of antigen-specific cells. Other c...
Before and 6 days after start of gluten challenge, blood samples will be collected and analysed by using HLA-tetramers to identify and purify CD4+ gluten-specific T cells by flow cytometry. T cells will undergo transcriptome analysis to get an insight in signalling of antigen-specific cells. Other cell populations like CD8+ T cells and ?? T cells will also be analyzed by flow cytometry.
Tracking Information
- NCT #
- NCT02464150
- Collaborators
- Stiftelsen Helse og Rehabilitering
- Helse Sor-Ost
- Investigators
- Principal Investigator: Knut EA Lundin, MD PhD Oslo University Hospital and University of Oslo
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