Phenotype, Genotype & Biomarkers in ALS and Related Disorders
Last updated on July 2021Recruitment
- Recruitment Status
- Enrolling by invitation
- Estimated Enrollment
- Same as current
Summary
- Conditions
- Amyotrophic Lateral Sclerosis
- Frontotemporal Dementia
- Hereditary Spastic Paraplegia
- Multisystem Proteinopathy
- Primary Lateral Sclerosis
- Progressive Muscular Atrophy
- Type
- Observational
- Design
- Observational Model: CohortTime Perspective: Prospective
Participation Requirements
- Age
- Younger than 125 years
- Gender
- Both males and females
Description
This study will recruit patients with ALS, ALS-FTD, PLS, HSP, and PMA, with a focus on incident cases. Patients with both familial and sporadic forms of these diseases will be enrolled and followed longitudinally using a standardized set of evaluations. Biological samples (blood, urine, CSF) will be...
This study will recruit patients with ALS, ALS-FTD, PLS, HSP, and PMA, with a focus on incident cases. Patients with both familial and sporadic forms of these diseases will be enrolled and followed longitudinally using a standardized set of evaluations. Biological samples (blood, urine, CSF) will be collected from all study participants, and will be used for biomarker discovery and validation. Family members of affected individuals may also be enrolled and asked to contribute DNA and biological samples to aid genetic and biomarker discovery.
Tracking Information
- NCT #
- NCT02327845
- Collaborators
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Center for Advancing Translational Science (NCATS)
- St. Jude Children's Research Hospital
- ALS Association
- Investigators
- Principal Investigator: Michael Benatar, DPhil University of Miami
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