Recruitment

Recruitment Status
Recruiting
Estimated Enrollment
500

Inclusion Criterias

Expected survival ≥ 3 months
Without dysfunction of heart, lung, liver, kidney and hematopoiesis
Karnofsky Performance Scores ≥ 60
...
Expected survival ≥ 3 months
Without dysfunction of heart, lung, liver, kidney and hematopoiesis
Karnofsky Performance Scores ≥ 60
Male or female patients with age between 18 and 75 years old
UICC/AJCC 2010 Stage T1-4 N0-3 M0
Nasopharyngeal cancer patients diagnosed by pathology or cytology

Exclusion Criterias

Application of colony stimulating factor such as erythropoietin
Radiotherapy uncompleted (≥ 1 fraction missing)
Without weekly complete blood count during radiotherapy
...
Application of colony stimulating factor such as erythropoietin
Radiotherapy uncompleted (≥ 1 fraction missing)
Without weekly complete blood count during radiotherapy
Distant metastases before or during radiotherapy
Karnofsky Performance Status Score < 70'
Signs of infection before radiotherapy.

Summary

Conditions
  • Blood Cell Count
  • Nasopharyngeal Neoplasms
  • Neoplasm Staging
  • Prognosis
Type
Observational
Design
  • Observational Model: Cohort
  • Time Perspective: Prospective

Participation Requirements

Age
Between 18 years and 75 years
Gender
Both males and females

Description

Totally 720 patients with non-metastatic nasopharyngeal carcinoma will be include and will be divided into 3 groups (Low Risk, Intermediate Risk and High Risk Groups) according to their prognostic index, which is on basis of blood cell count indexes and TNM stage. The 3 groups of patients will under...

Totally 720 patients with non-metastatic nasopharyngeal carcinoma will be include and will be divided into 3 groups (Low Risk, Intermediate Risk and High Risk Groups) according to their prognostic index, which is on basis of blood cell count indexes and TNM stage. The 3 groups of patients will undergo a radical radiotherapy or chemoradiotherapy and be followed until death or the end of the study. Comparison on survivals of the 3 groups will be made to validate the accuracy of the prognostic index. And comparison on prediction efficacy between prognostic index and TNM staging system will be made.

Inclusion Criterias

Expected survival ≥ 3 months
Without dysfunction of heart, lung, liver, kidney and hematopoiesis
Karnofsky Performance Scores ≥ 60
...
Expected survival ≥ 3 months
Without dysfunction of heart, lung, liver, kidney and hematopoiesis
Karnofsky Performance Scores ≥ 60
Male or female patients with age between 18 and 75 years old
UICC/AJCC 2010 Stage T1-4 N0-3 M0
Nasopharyngeal cancer patients diagnosed by pathology or cytology

Exclusion Criterias

Application of colony stimulating factor such as erythropoietin
Radiotherapy uncompleted (≥ 1 fraction missing)
Without weekly complete blood count during radiotherapy
...
Application of colony stimulating factor such as erythropoietin
Radiotherapy uncompleted (≥ 1 fraction missing)
Without weekly complete blood count during radiotherapy
Distant metastases before or during radiotherapy
Karnofsky Performance Status Score < 70'
Signs of infection before radiotherapy.

Locations

Hefei, Anhui, 230001
Guangzhou, Guangdong, 510060
Bengbu, Anhui, 233004
Guangzhou, Guangdong, 510120
Luzhou, Sichuan, 646000
...
Hefei, Anhui, 230001
Guangzhou, Guangdong, 510060
Bengbu, Anhui, 233004
Guangzhou, Guangdong, 510120
Luzhou, Sichuan, 646000
Shaoyang, Hunan, 422000

Tracking Information

NCT #
NCT02211677
Collaborators
Not Provided
Investigators
  • Principal Investigator: Yun-fei Xia, MD Sun Yat-sen University
  • Yun-fei Xia, MD Sun Yat-sen University