Recruitment

Recruitment Status
Completed
Estimated Enrollment
28

Inclusion Criteria

Clinical and/or genetic diagnosis of ocular or oculocutaneous albinism
At least one reliable central macular pigment optical density (MPOD) measurement captured on the enrollment visit in at least one eligible eye
Best corrected visual acuity of 20/200 or better in one or both eligible eyes (eyes that confirmed to be eligible by the MPOD testing).
...
Clinical and/or genetic diagnosis of ocular or oculocutaneous albinism
At least one reliable central macular pigment optical density (MPOD) measurement captured on the enrollment visit in at least one eligible eye
Best corrected visual acuity of 20/200 or better in one or both eligible eyes (eyes that confirmed to be eligible by the MPOD testing).
Ocular media allowing acceptable visualization of the retina.
Ocular media allowing acceptable quality of the ocular coherence tomography (OCT) and/or fundus autofluorescence (FAF) scans.
Age of 12 years old and older

Exclusion Criteria

Participation in a clinical trial requiring visual testing or administration of a drug (marketed or investigational) within 60 days before entry in the study (the day informed consent is signed)
Evidence of present or past retinal macular condition other than congenital foveal hypoplasia
History of gastrointestinal disease that would interfere with absorption of lutein and zeaxanthin
...
Participation in a clinical trial requiring visual testing or administration of a drug (marketed or investigational) within 60 days before entry in the study (the day informed consent is signed)
Evidence of present or past retinal macular condition other than congenital foveal hypoplasia
History of gastrointestinal disease that would interfere with absorption of lutein and zeaxanthin
Persons taking lutein and/or zeaxanthin supplements over the past 6 months
Pregnant or planning to become pregnant
Any other condition which, in the opinion of the investigators, is likely to interfere with the successful collection of the measures required for the study
Inability to communicate or cooperate with the investigator due to cognitive impairment or poor general health

Summary

Conditions
  • Ocular Albinism (OA)
  • Oculocutaneous Albinism (OCA)
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 12 years and 125 years
Gender
Both males and females

Description

Ocular and oculocutaneous albinism represent a spectrum of disorders with absent or significantly diminished amount of melanin either across different body tissues - skin, hair, eye (Oculocutaneous Albinism 1 and 2), or exclusively in eye tissues only (Ocular Albinism 1) . The functionality and the ...

Ocular and oculocutaneous albinism represent a spectrum of disorders with absent or significantly diminished amount of melanin either across different body tissues - skin, hair, eye (Oculocutaneous Albinism 1 and 2), or exclusively in eye tissues only (Ocular Albinism 1) . The functionality and the clinical findings are diverse (the phenotype), and no direct correlation has been established to the underlying mutations (genotype). The common ocular phenotype includes iris transillumination, foveal hypoplasia, nystagmus, reduced visual acuity, refractive error, photosensitivity and abnormal development of the visual pathways with characteristic abnormal routing of ganglion cell axons in the chiasma, resulting in abnormal visually evoked potentials. Current treatment options are limited to optical methods and low vision aids. The mechanism of melanin pigment formation in the RPE cells and its role in the visual pathways and structures development is not completely understood, but a correlation was found between the amount of fundus pigmentation and visual function in albino patients. The absent pigmentation within the retinal pigment epithelium (RPE) may thus contribute to visual performance deficits. The macular pigment (MP) consists of two main carotenoids, lutein and zeaxanthin, which are concentrated in the macular region of the retina. MP is hypothesized to function via a protective mechanism by absorbing blue light incident on the retina thereby reducing oxidative damage to the underlying photoreceptors. It is also thought to improve visual function via reduction of chromatic aberration and glare. It is currently unclear as to how the variability in macular pigment optical density (MPOD) affects congenital retinal conditions. The MP would, however, be a hypothetical and good candidate to improve visual performance - simply by increasing pigmentation, reducing light scatter and thus glare sensitivity. As this pigment is not produced in the retina, but is absorbed via diet, it can be manipulated by alteration in diet and supplementation thereby providing potential therapy for retinal diseases. It is however necessary first to see if MPOD levels are measurable in this disorder before dietary advice can be provided after completion of the LUVIA study. Further to this, evaluation of both the structural and functional properties of the retina will provide greater insight into the possible function of MP in this retinal disease including whether supplementation would be of benefit.

Inclusion Criteria

Clinical and/or genetic diagnosis of ocular or oculocutaneous albinism
At least one reliable central macular pigment optical density (MPOD) measurement captured on the enrollment visit in at least one eligible eye
Best corrected visual acuity of 20/200 or better in one or both eligible eyes (eyes that confirmed to be eligible by the MPOD testing).
...
Clinical and/or genetic diagnosis of ocular or oculocutaneous albinism
At least one reliable central macular pigment optical density (MPOD) measurement captured on the enrollment visit in at least one eligible eye
Best corrected visual acuity of 20/200 or better in one or both eligible eyes (eyes that confirmed to be eligible by the MPOD testing).
Ocular media allowing acceptable visualization of the retina.
Ocular media allowing acceptable quality of the ocular coherence tomography (OCT) and/or fundus autofluorescence (FAF) scans.
Age of 12 years old and older

Exclusion Criteria

Participation in a clinical trial requiring visual testing or administration of a drug (marketed or investigational) within 60 days before entry in the study (the day informed consent is signed)
Evidence of present or past retinal macular condition other than congenital foveal hypoplasia
History of gastrointestinal disease that would interfere with absorption of lutein and zeaxanthin
...
Participation in a clinical trial requiring visual testing or administration of a drug (marketed or investigational) within 60 days before entry in the study (the day informed consent is signed)
Evidence of present or past retinal macular condition other than congenital foveal hypoplasia
History of gastrointestinal disease that would interfere with absorption of lutein and zeaxanthin
Persons taking lutein and/or zeaxanthin supplements over the past 6 months
Pregnant or planning to become pregnant
Any other condition which, in the opinion of the investigators, is likely to interfere with the successful collection of the measures required for the study
Inability to communicate or cooperate with the investigator due to cognitive impairment or poor general health

Tracking Information

NCT #
NCT02200263
Collaborators
Clark Charitable Foundation Inc.
Investigators
  • Principal Investigator: Neil Bressler, MD Johns Hopkins University Study Director: Mary E. Frey Johns Hopkins University
  • Neil Bressler, MD Johns Hopkins University Study Director: Mary E. Frey Johns Hopkins University
About Us
Innovation
Privacy
Terms
Copyright
Get Well Soon © Copyright 2024