Improving Glycaemic Control With L-carnitine
Last updated on April 2022Recruitment
- Recruitment Status
- Unknown status
Inclusion Criteria
- Age 18-60 years old
- Body mass index (BMI) 27-37 kg/m2
- Understand verbal and/or written explanation of the study requirements
- ...
- Age 18-60 years old
- Body mass index (BMI) 27-37 kg/m2
- Understand verbal and/or written explanation of the study requirements
- Not taking anti-diabetes medication other than metformin
- Type 2 diabetes mellitus reasonably well controlled (HbA1c less than or equal to 58 mmol/mol) on diet therapy or metformin alone
- Male
Exclusion Criteria
- Cerebrovascular disease
- Active respiratory disease
- Active cardiovascular disease (current angina, myocardial infarct, or coronary artery surgery/angioplasty within 12 months)
- ...
- Cerebrovascular disease
- Active respiratory disease
- Active cardiovascular disease (current angina, myocardial infarct, or coronary artery surgery/angioplasty within 12 months)
- Primary muscle disorders
- Neurological disease e.g. epilepsy, Parkinsons disease
- Other medications that may affect glucose tolerance (e.g. corticosteroids), muscle metabolism, or safety (e.g. anticoagulants)
- Malignancy (excluding localised basal and squamous cell skin cancer)
- Active gastrointestinal or liver disease
- Metabolic diseases (stable treated hypothyroidism allowed)
- Renal impairment (eGFR <60 ml/min)
- Clotting dysfunction
- Anti-diabetes medication other than metformin
- Any other conditions in addition to the above that the investigators consider may affect study measurements or safety
Summary
- Conditions
- Type 2 Diabetes
- Type
- Interventional
- Phase
- Phase 2
- Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
Participation Requirements
- Age
- Between 18 years and 60 years
- Gender
- Only males
Inclusion Criteria
- Age 18-60 years old
- Body mass index (BMI) 27-37 kg/m2
- Understand verbal and/or written explanation of the study requirements
- ...
- Age 18-60 years old
- Body mass index (BMI) 27-37 kg/m2
- Understand verbal and/or written explanation of the study requirements
- Not taking anti-diabetes medication other than metformin
- Type 2 diabetes mellitus reasonably well controlled (HbA1c less than or equal to 58 mmol/mol) on diet therapy or metformin alone
- Male
Exclusion Criteria
- Cerebrovascular disease
- Active respiratory disease
- Active cardiovascular disease (current angina, myocardial infarct, or coronary artery surgery/angioplasty within 12 months)
- ...
- Cerebrovascular disease
- Active respiratory disease
- Active cardiovascular disease (current angina, myocardial infarct, or coronary artery surgery/angioplasty within 12 months)
- Primary muscle disorders
- Neurological disease e.g. epilepsy, Parkinsons disease
- Other medications that may affect glucose tolerance (e.g. corticosteroids), muscle metabolism, or safety (e.g. anticoagulants)
- Malignancy (excluding localised basal and squamous cell skin cancer)
- Active gastrointestinal or liver disease
- Metabolic diseases (stable treated hypothyroidism allowed)
- Renal impairment (eGFR <60 ml/min)
- Clotting dysfunction
- Anti-diabetes medication other than metformin
- Any other conditions in addition to the above that the investigators consider may affect study measurements or safety
Tracking Information
- NCT #
- NCT02197299
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Francis B Stephens, PhD The University of Nottingham
- Francis B Stephens, PhD The University of Nottingham