Recruitment

Recruitment Status
Unknown status

Inclusion Criterias

Age 18-60 years old
Understand verbal and/or written explanation of the study requirements
Type 2 diabetes mellitus reasonably well controlled (HbA1c less than or equal to 58 mmol/mol) on diet therapy or metformin alone
...
Age 18-60 years old
Understand verbal and/or written explanation of the study requirements
Type 2 diabetes mellitus reasonably well controlled (HbA1c less than or equal to 58 mmol/mol) on diet therapy or metformin alone
Body mass index (BMI) 27-37 kg/m2
Male
Not taking anti-diabetes medication other than metformin

Exclusion Criterias

Any other conditions in addition to the above that the investigators consider may affect study measurements or safety
Other medications that may affect glucose tolerance (e.g. corticosteroids), muscle metabolism, or safety (e.g. anticoagulants)
Metabolic diseases (stable treated hypothyroidism allowed)
...
Any other conditions in addition to the above that the investigators consider may affect study measurements or safety
Other medications that may affect glucose tolerance (e.g. corticosteroids), muscle metabolism, or safety (e.g. anticoagulants)
Metabolic diseases (stable treated hypothyroidism allowed)
Neurological disease e.g. epilepsy, Parkinsons disease
Active gastrointestinal or liver disease
Active respiratory disease
Anti-diabetes medication other than metformin
Malignancy (excluding localised basal and squamous cell skin cancer)
Active cardiovascular disease (current angina, myocardial infarct, or coronary artery surgery/angioplasty within 12 months)
Renal impairment (eGFR <60 ml/min)
Clotting dysfunction
Cerebrovascular disease
Primary muscle disorders

Summary

Conditions
Type 2 Diabetes
Type
Interventional
Phase
Phase 2
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double (Participant, Investigator)
  • Primary Purpose: Basic Science

Participation Requirements

Age
Between 18 years and 60 years
Gender
Only males

Inclusion Criterias

Age 18-60 years old
Understand verbal and/or written explanation of the study requirements
Type 2 diabetes mellitus reasonably well controlled (HbA1c less than or equal to 58 mmol/mol) on diet therapy or metformin alone
...
Age 18-60 years old
Understand verbal and/or written explanation of the study requirements
Type 2 diabetes mellitus reasonably well controlled (HbA1c less than or equal to 58 mmol/mol) on diet therapy or metformin alone
Body mass index (BMI) 27-37 kg/m2
Male
Not taking anti-diabetes medication other than metformin

Exclusion Criterias

Any other conditions in addition to the above that the investigators consider may affect study measurements or safety
Other medications that may affect glucose tolerance (e.g. corticosteroids), muscle metabolism, or safety (e.g. anticoagulants)
Metabolic diseases (stable treated hypothyroidism allowed)
...
Any other conditions in addition to the above that the investigators consider may affect study measurements or safety
Other medications that may affect glucose tolerance (e.g. corticosteroids), muscle metabolism, or safety (e.g. anticoagulants)
Metabolic diseases (stable treated hypothyroidism allowed)
Neurological disease e.g. epilepsy, Parkinsons disease
Active gastrointestinal or liver disease
Active respiratory disease
Anti-diabetes medication other than metformin
Malignancy (excluding localised basal and squamous cell skin cancer)
Active cardiovascular disease (current angina, myocardial infarct, or coronary artery surgery/angioplasty within 12 months)
Renal impairment (eGFR <60 ml/min)
Clotting dysfunction
Cerebrovascular disease
Primary muscle disorders

Locations

Nottingham, NG72UH
Nottingham, NG72UH

Tracking Information

NCT #
NCT02197299
Collaborators
Not Provided
Investigators
  • Principal Investigator: Francis B Stephens, PhD The University of Nottingham
  • Francis B Stephens, PhD The University of Nottingham