Dietary Intervention Replacing Carbohydrate With Protein and Fat Has Greater Effect on Peripheral Blood Mononuclear Cell Metabolites Than on Plasma Metabolites in Patients With Prediabetes or Type-2 Diabetes
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
Inclusion Criteria
- or newly diagnosed type-2 diabetes (fasting glucose ≥126 mg/dL)
- subjects who had IFG (100≤ fasting glucose <126 mg/dL)
- or newly diagnosed type-2 diabetes (fasting glucose ≥126 mg/dL)
- subjects who had IFG (100≤ fasting glucose <126 mg/dL)
Exclusion Criteria
- current and/or past history of cardiovascular disease including angina
- liver or kidney dysfunction
- pregnancy or lactation
- ...
- current and/or past history of cardiovascular disease including angina
- liver or kidney dysfunction
- pregnancy or lactation
- taking medications or supplements
- thyroid or pituitary disease
Summary
- Conditions
- Prediabetes
- Type 2 Diabetes
- Type-2 Diabetes
- Type
- Interventional
- Phase
- Phase 2
- Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
Participation Requirements
- Age
- Between 40 years and 70 years
- Gender
- Both males and females
Description
Eighty nonobese patients (aged 40-70 years) with prediabetes or newly diagnosed type-2 diabetes were randomly assigned to a control group (normal diet with refined rice) or a whole-grain group (replacement of refined rice with whole-grains and legumes). This dietary intervention replaced approximate...
Eighty nonobese patients (aged 40-70 years) with prediabetes or newly diagnosed type-2 diabetes were randomly assigned to a control group (normal diet with refined rice) or a whole-grain group (replacement of refined rice with whole-grains and legumes). This dietary intervention replaced approximately 7% of carbohydrate-derived energy with approximately 4% of protein-derived energy and approximately 3% of fat-derived energy.
Inclusion Criteria
- or newly diagnosed type-2 diabetes (fasting glucose ≥126 mg/dL)
- subjects who had IFG (100≤ fasting glucose <126 mg/dL)
- or newly diagnosed type-2 diabetes (fasting glucose ≥126 mg/dL)
- subjects who had IFG (100≤ fasting glucose <126 mg/dL)
Exclusion Criteria
- current and/or past history of cardiovascular disease including angina
- liver or kidney dysfunction
- pregnancy or lactation
- ...
- current and/or past history of cardiovascular disease including angina
- liver or kidney dysfunction
- pregnancy or lactation
- taking medications or supplements
- thyroid or pituitary disease
Tracking Information
- NCT #
- NCT02191644
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Jong Ho Lee, PhD Yonsei University
- Jong Ho Lee, PhD Yonsei University
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