Effects of Onion Peel Extract on Endothelial Function
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
Inclusion Criteria
- age 20 to 60 years
- BMI >23 kg/m2
- abdominal circumference > 90 cm in males or >85 cm in females
- age 20 to 60 years
- BMI >23 kg/m2
- abdominal circumference > 90 cm in males or >85 cm in females
Exclusion Criteria
- cerebrovascular disease
- pregnancy
- hypertension (>140/90 mmHg),
- ...
- cerebrovascular disease
- pregnancy
- hypertension (>140/90 mmHg),
- diabetes
- liver disease (bilirubin level >2 mg/dl)
- any cardiovascular disease,
- thyroid disease
- kidney disease,
Summary
- Conditions
- Healthy
- Obese
- Overweight
- Type
- Interventional
- Phase
- Phase 4
- Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Supportive Care
Participation Requirements
- Age
- Between 20 years and 60 years
- Gender
- Both males and females
Description
Epidemiological studies have shown a rapid increase in the prevalence of overweight and obesity, not only in adults but also in children and adolescents, thus increasing the risk of early development of cardiovascular disease (CVD). Quercetin, found abundantly in onion, prevents the induction of end...
Epidemiological studies have shown a rapid increase in the prevalence of overweight and obesity, not only in adults but also in children and adolescents, thus increasing the risk of early development of cardiovascular disease (CVD). Quercetin, found abundantly in onion, prevents the induction of endothelial dysfunction, superoxide production, and overexpression by angiotensin II in the rat aorta. Furthermore, in our previous study we showed that supplementation with quercetin-rich onion peel extract (OPE) influenced adipokine expression, thus addressing its modulatory effect on obesity-induced inflammation, and improved insulin resistance by alleviating the metabolic dysregulation of free fatty acids, suppressing oxidative stress, upregulating glucose uptake, and downregulating inflammatory gene expression. But there are limited studies on the relationship between quercetin supplementation and endothelial dysfunction in humans.
Inclusion Criteria
- age 20 to 60 years
- BMI >23 kg/m2
- abdominal circumference > 90 cm in males or >85 cm in females
- age 20 to 60 years
- BMI >23 kg/m2
- abdominal circumference > 90 cm in males or >85 cm in females
Exclusion Criteria
- cerebrovascular disease
- pregnancy
- hypertension (>140/90 mmHg),
- ...
- cerebrovascular disease
- pregnancy
- hypertension (>140/90 mmHg),
- diabetes
- liver disease (bilirubin level >2 mg/dl)
- any cardiovascular disease,
- thyroid disease
- kidney disease,
Tracking Information
- NCT #
- NCT02180022
- Collaborators
- Kyunghee University
- Investigators
- Principal Investigator: Weon Kim, MD, PhD Kyung Hee University Hospital
- Weon Kim, MD, PhD Kyung Hee University Hospital
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