Recruitment

Recruitment Status
Completed

Inclusion Criteria

abdominal circumference > 90 cm in males or >85 cm in females
age 20 to 60 years
BMI >23 kg/m2
abdominal circumference > 90 cm in males or >85 cm in females
age 20 to 60 years
BMI >23 kg/m2

Exclusion Criteria

kidney disease,
thyroid disease
liver disease (bilirubin level >2 mg/dl)
...
kidney disease,
thyroid disease
liver disease (bilirubin level >2 mg/dl)
pregnancy
any cardiovascular disease,
diabetes
hypertension (>140/90 mmHg),
cerebrovascular disease

Summary

Conditions
  • Healthy
  • Obese
  • Overweight
Type
Interventional
Phase
Phase 4
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Supportive Care

Participation Requirements

Age
Between 20 years and 60 years
Gender
Both males and females

Description

Epidemiological studies have shown a rapid increase in the prevalence of overweight and obesity, not only in adults but also in children and adolescents, thus increasing the risk of early development of cardiovascular disease (CVD). Quercetin, found abundantly in onion, prevents the induction of end...

Epidemiological studies have shown a rapid increase in the prevalence of overweight and obesity, not only in adults but also in children and adolescents, thus increasing the risk of early development of cardiovascular disease (CVD). Quercetin, found abundantly in onion, prevents the induction of endothelial dysfunction, superoxide production, and overexpression by angiotensin II in the rat aorta. Furthermore, in our previous study we showed that supplementation with quercetin-rich onion peel extract (OPE) influenced adipokine expression, thus addressing its modulatory effect on obesity-induced inflammation, and improved insulin resistance by alleviating the metabolic dysregulation of free fatty acids, suppressing oxidative stress, upregulating glucose uptake, and downregulating inflammatory gene expression. But there are limited studies on the relationship between quercetin supplementation and endothelial dysfunction in humans.

Inclusion Criteria

abdominal circumference > 90 cm in males or >85 cm in females
age 20 to 60 years
BMI >23 kg/m2
abdominal circumference > 90 cm in males or >85 cm in females
age 20 to 60 years
BMI >23 kg/m2

Exclusion Criteria

kidney disease,
thyroid disease
liver disease (bilirubin level >2 mg/dl)
...
kidney disease,
thyroid disease
liver disease (bilirubin level >2 mg/dl)
pregnancy
any cardiovascular disease,
diabetes
hypertension (>140/90 mmHg),
cerebrovascular disease

Tracking Information

NCT #
NCT02180022
Collaborators
Kyunghee University
Investigators
  • Principal Investigator: Weon Kim, MD, PhD Kyung Hee University Hospital
  • Weon Kim, MD, PhD Kyung Hee University Hospital