Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
Inclusion Criteria
- More than one of the following:
- More than one of the following:
Exclusion Criteria
- (1)patients younger than 18 years of age; (2)agranulocytosis (granulocyte counts,0.5×10^9/L); (3) those discharged within 24 h; (4) those diagnosed with HIV infection or cancer; and (5) patients who refused to participate.
- (1)patients younger than 18 years of age; (2)agranulocytosis (granulocyte counts,0.5×10^9/L); (3) those discharged within 24 h; (4) those diagnosed with HIV infection or cancer; and (5) patients who refused to participate.
Summary
- Conditions
- Sepsis
- Septic Shock
- Severe Sepsis
- Design
- Observational Model: Cohort
- Time Perspective: Prospective
Participation Requirements
- Age
- Between 18 years and 80 years
- Gender
- Both males and females
Description
In this study, we will collect the peripheral blood of 1,3,5,7,10,14 day after diagnose of sepsis.All the patients rolled in this study will be divided into three groups which is sepsis, severe sepsis and septic shock group according their severity. Then,the flow cytometry will be used to detect the...
In this study, we will collect the peripheral blood of 1,3,5,7,10,14 day after diagnose of sepsis.All the patients rolled in this study will be divided into three groups which is sepsis, severe sepsis and septic shock group according their severity. Then,the flow cytometry will be used to detect the express of Tim-3 on monocyte and ELISA will be used to exam the plasm soluble Tim-3.IL-6,IL-10,IL-12 and TNF-αin the peripheral blood will also be detected. We would like to find a new marker to predict the severity and prognosis of sepsis patients.
Inclusion Criteria
- More than one of the following:
- More than one of the following:
Exclusion Criteria
- (1)patients younger than 18 years of age; (2)agranulocytosis (granulocyte counts,0.5×10^9/L); (3) those discharged within 24 h; (4) those diagnosed with HIV infection or cancer; and (5) patients who refused to participate.
- (1)patients younger than 18 years of age; (2)agranulocytosis (granulocyte counts,0.5×10^9/L); (3) those discharged within 24 h; (4) those diagnosed with HIV infection or cancer; and (5) patients who refused to participate.
Tracking Information
- NCT #
- NCT02180009
- Collaborators
- Beijing Institute of Basic Medical Science
- Investigators
- Principal Investigator: Lixin Xie, PhD & MD Head of Department of Respiratory Medicine,Chinese PLA Gerneral Hospital
- Lixin Xie, PhD & MD Head of Department of Respiratory Medicine,Chinese PLA Gerneral Hospital