Methotrexate Polyglutamates as a Marker of Clinical Response and Toxicity in the Treatment of Psoriasis
Last updated on April 2022Recruitment
- Recruitment Status
- Unknown status
Inclusion Criteria
- Taking oral or subcutaneous methotrexate
- Measurement of methotrexate polyglutamates on at least one occasion during therapy.
- Patients with psoriasis
- ...
- Taking oral or subcutaneous methotrexate
- Measurement of methotrexate polyglutamates on at least one occasion during therapy.
- Patients with psoriasis
- Patients who have given written informed consent
Exclusion Criteria
- Unable to consent
- Not taking methotrexate
- Unable to consent
- Not taking methotrexate
Summary
- Conditions
- Injury of Liver
- Psoriasis Chronic
- Type
- Observational
- Design
- Observational Model: Cohort
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Data for this study is drawn from the BSTOP (Biomarkers of Systemic Treatment Outcomes in Psoriasis) cohort. This is a multi-centre, prospective, cohort study to establish clinically relevant biomarkers and pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis.
Data for this study is drawn from the BSTOP (Biomarkers of Systemic Treatment Outcomes in Psoriasis) cohort. This is a multi-centre, prospective, cohort study to establish clinically relevant biomarkers and pharmacogenetic markers of systemic treatment outcomes in patients with severe psoriasis.
Inclusion Criteria
- Taking oral or subcutaneous methotrexate
- Measurement of methotrexate polyglutamates on at least one occasion during therapy.
- Patients with psoriasis
- ...
- Taking oral or subcutaneous methotrexate
- Measurement of methotrexate polyglutamates on at least one occasion during therapy.
- Patients with psoriasis
- Patients who have given written informed consent
Exclusion Criteria
- Unable to consent
- Not taking methotrexate
- Unable to consent
- Not taking methotrexate
Tracking Information
- NCT #
- NCT02174354
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Catherine H Smith, MD Kings College London and Guys and St Thomas' NHS Foundation Trust
- Catherine H Smith, MD Kings College London and Guys and St Thomas' NHS Foundation Trust
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