Correlation of Pain, Obesity and Fertility Potential.
Last updated on April 2022Recruitment
- Recruitment Status
- Unknown status
Inclusion Criteria
- Men between 18-45 years with low back pain or knee pain recruited among referees to the orthopaedic outpatient clinics at Aalborg University Hospital
- Pain more than 3 months
- Patients can be on a daily use of Paracetamol 1 gram x 4, NSAID x 3-4 or combined
- ...
- Men between 18-45 years with low back pain or knee pain recruited among referees to the orthopaedic outpatient clinics at Aalborg University Hospital
- Pain more than 3 months
- Patients can be on a daily use of Paracetamol 1 gram x 4, NSAID x 3-4 or combined
- Regarding low back pain the LBPRS >9, knee pain the KOOS <75 (0-100, i.c. 100 = no problems)
- Healthy men in the age 18-45 years (matched with enrolled patients)
- Patients will be included regardless of their BMI but will be put in their respective BMI subgroup after the required measurements have been taken
Exclusion Criteria
- Pain rating
- Drug addiction defined as the use of cannabis, opioids or other psycho drugs
- Medication
- ...
- Pain rating
- Drug addiction defined as the use of cannabis, opioids or other psycho drugs
- Medication
- Ongoing infection
- Previous neurologic, musculoskeletal or mental diseases
- Patients taking Morphine drugs
- Malignancy
- Patients with a pain rate below 3
- Lack of ability to cooperate
Summary
- Conditions
- Overweight and Obesity
- Type
- Observational
- Design
- Observational Model: Case-Control
- Time Perspective: Retrospective
Participation Requirements
- Age
- Between 18 years and 45 years
- Gender
- Only males
Description
Obesity is associated with several disorders including chronic musculoskeletal pain. For example obesity has been implicated in the development or progression of low back pain and knee osteoarthritis. The mechanism by which obesity causes lumbar back pain is poorly understood, but the contribution o...
Obesity is associated with several disorders including chronic musculoskeletal pain. For example obesity has been implicated in the development or progression of low back pain and knee osteoarthritis. The mechanism by which obesity causes lumbar back pain is poorly understood, but the contribution of both mechanical and system factors is likely. Direct mechanical stress on the intervertebral discs and adjacent structures are suspected to be mechanisms through which obesity affects the spine, leading to subsequent low back pain. The link between obesity and knee osteoarthritis has also been demonstrated, but potential factors underlying the association of obesity with knee osteoarthritis has not entirely been elucidated. It is a well-known fact that obesity leads to an excess load on the joint, increased cartilage turnover, increased collagen type 2 degradation products and increased risk of degenerative meniscal lesions. Although all of these factors have been proposed to lead to knee osteoarthritis, no causal relationship has been demonstrated.
Inclusion Criteria
- Men between 18-45 years with low back pain or knee pain recruited among referees to the orthopaedic outpatient clinics at Aalborg University Hospital
- Pain more than 3 months
- Patients can be on a daily use of Paracetamol 1 gram x 4, NSAID x 3-4 or combined
- ...
- Men between 18-45 years with low back pain or knee pain recruited among referees to the orthopaedic outpatient clinics at Aalborg University Hospital
- Pain more than 3 months
- Patients can be on a daily use of Paracetamol 1 gram x 4, NSAID x 3-4 or combined
- Regarding low back pain the LBPRS >9, knee pain the KOOS <75 (0-100, i.c. 100 = no problems)
- Healthy men in the age 18-45 years (matched with enrolled patients)
- Patients will be included regardless of their BMI but will be put in their respective BMI subgroup after the required measurements have been taken
Exclusion Criteria
- Pain rating
- Drug addiction defined as the use of cannabis, opioids or other psycho drugs
- Medication
- ...
- Pain rating
- Drug addiction defined as the use of cannabis, opioids or other psycho drugs
- Medication
- Ongoing infection
- Previous neurologic, musculoskeletal or mental diseases
- Patients taking Morphine drugs
- Malignancy
- Patients with a pain rate below 3
- Lack of ability to cooperate
Tracking Information
- NCT #
- NCT02168517
- Collaborators
- Aalborg University
- Investigators
- Study Director: Sten Rasmussen, M.D. Clinic for Neuro- and Orthopaedic Diseases, Aalborg University Hospital Study Director: Hans I. Nielsen, PhD Department of Health Science and Technology, Aalborg University Principal Investigator: Fereshteh Dardmeh, PhD stud. Department of Health Science and Technology, Aalborg University Study Chair: Parisa Gazerani, PhD Department of Health Science and Technology, Aalborg University Study Chair: Hiva Alipour, PhD stud. Department of Health Science and Technology, Aalborg University
- Study Director: Sten Rasmussen, M.D. Clinic for Neuro- and Orthopaedic Diseases, Aalborg University Hospital Study Director: Hans I. Nielsen, PhD Department of Health Science and Technology, Aalborg University Fereshteh Dardmeh, PhD stud. Department of Health Science and Technology, Aalborg University Study Chair: Parisa Gazerani, PhD Department of Health Science and Technology, Aalborg University Study Chair: Hiva Alipour, PhD stud. Department of Health Science and Technology, Aalborg University
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