Recruitment

Recruitment Status
Unknown status

Inclusion Criterias

Healthy men in the age 18-45 years (matched with enrolled patients)
Patients will be included regardless of their BMI but will be put in their respective BMI subgroup after the required measurements have been taken
Pain more than 3 months
...
Healthy men in the age 18-45 years (matched with enrolled patients)
Patients will be included regardless of their BMI but will be put in their respective BMI subgroup after the required measurements have been taken
Pain more than 3 months
Regarding low back pain the LBPRS >9, knee pain the KOOS <75 (0-100, i.c. 100 = no problems)
Patients can be on a daily use of Paracetamol 1 gram x 4, NSAID x 3-4 or combined
Men between 18-45 years with low back pain or knee pain recruited among referees to the orthopaedic outpatient clinics at Aalborg University Hospital

Exclusion Criterias

Lack of ability to cooperate
Patients with a pain rate below 3
Previous neurologic, musculoskeletal or mental diseases
...
Lack of ability to cooperate
Patients with a pain rate below 3
Previous neurologic, musculoskeletal or mental diseases
Drug addiction defined as the use of cannabis, opioids or other psycho drugs
Pain rating
Malignancy
Ongoing infection
Medication
Patients taking Morphine drugs

Summary

Conditions
Overweight and Obesity
Type
Observational
Design
  • Observational Model: Case-Control
  • Time Perspective: Retrospective

Participation Requirements

Age
Between 18 years and 45 years
Gender
Only males

Description

Obesity is associated with several disorders including chronic musculoskeletal pain. For example obesity has been implicated in the development or progression of low back pain and knee osteoarthritis. The mechanism by which obesity causes lumbar back pain is poorly understood, but the contribution o...

Obesity is associated with several disorders including chronic musculoskeletal pain. For example obesity has been implicated in the development or progression of low back pain and knee osteoarthritis. The mechanism by which obesity causes lumbar back pain is poorly understood, but the contribution of both mechanical and system factors is likely. Direct mechanical stress on the intervertebral discs and adjacent structures are suspected to be mechanisms through which obesity affects the spine, leading to subsequent low back pain. The link between obesity and knee osteoarthritis has also been demonstrated, but potential factors underlying the association of obesity with knee osteoarthritis has not entirely been elucidated. It is a well-known fact that obesity leads to an excess load on the joint, increased cartilage turnover, increased collagen type 2 degradation products and increased risk of degenerative meniscal lesions. Although all of these factors have been proposed to lead to knee osteoarthritis, no causal relationship has been demonstrated.

Inclusion Criterias

Healthy men in the age 18-45 years (matched with enrolled patients)
Patients will be included regardless of their BMI but will be put in their respective BMI subgroup after the required measurements have been taken
Pain more than 3 months
...
Healthy men in the age 18-45 years (matched with enrolled patients)
Patients will be included regardless of their BMI but will be put in their respective BMI subgroup after the required measurements have been taken
Pain more than 3 months
Regarding low back pain the LBPRS >9, knee pain the KOOS <75 (0-100, i.c. 100 = no problems)
Patients can be on a daily use of Paracetamol 1 gram x 4, NSAID x 3-4 or combined
Men between 18-45 years with low back pain or knee pain recruited among referees to the orthopaedic outpatient clinics at Aalborg University Hospital

Exclusion Criterias

Lack of ability to cooperate
Patients with a pain rate below 3
Previous neurologic, musculoskeletal or mental diseases
...
Lack of ability to cooperate
Patients with a pain rate below 3
Previous neurologic, musculoskeletal or mental diseases
Drug addiction defined as the use of cannabis, opioids or other psycho drugs
Pain rating
Malignancy
Ongoing infection
Medication
Patients taking Morphine drugs

Locations

Aalborg, DK-9000
Aalborg, DK-9000

Tracking Information

NCT #
NCT02168517
Collaborators
Aalborg University
Investigators
  • Study Director: Sten Rasmussen, M.D. Clinic for Neuro- and Orthopaedic Diseases, Aalborg University Hospital Study Director: Hans I. Nielsen, PhD Department of Health Science and Technology, Aalborg University Principal Investigator: Fereshteh Dardmeh, PhD stud. Department of Health Science and Technology, Aalborg University Study Chair: Parisa Gazerani, PhD Department of Health Science and Technology, Aalborg University Study Chair: Hiva Alipour, PhD stud. Department of Health Science and Technology, Aalborg University
  • Study Director: Sten Rasmussen, M.D. Clinic for Neuro- and Orthopaedic Diseases, Aalborg University Hospital Study Director: Hans I. Nielsen, PhD Department of Health Science and Technology, Aalborg University Fereshteh Dardmeh, PhD stud. Department of Health Science and Technology, Aalborg University Study Chair: Parisa Gazerani, PhD Department of Health Science and Technology, Aalborg University Study Chair: Hiva Alipour, PhD stud. Department of Health Science and Technology, Aalborg University