Recruitment

Recruitment Status
Completed
Estimated Enrollment
30

Inclusion Criterias

Diagnosed with Facioscapulohumeral muscular dystrophy or
healthy matched control, matched for age, gender, BMI and activity level.
Diagnosed with Facioscapulohumeral muscular dystrophy or
healthy matched control, matched for age, gender, BMI and activity level.

Exclusion Criterias

Pregnant or breastfeeding women.
Physical or mental condition, which prevent participating in the study protocol.
More than 1 hour cardiac exercise weekly before inclusion.
...
Pregnant or breastfeeding women.
Physical or mental condition, which prevent participating in the study protocol.
More than 1 hour cardiac exercise weekly before inclusion.
Physical or mental condition, which could influence the results.
Participating in other studies, which could influence the results.

Summary

Conditions
FSHD - Facioscapulohumeral Muscular Dystrophy
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: None (Open Label)
  • Primary Purpose: Supportive Care

Participation Requirements

Age
Between 18 years and 70 years
Gender
Both males and females

Description

Clinical trials have in recent years demonstrated that aerobic exercise, are both effective and safe in patients with facioscapulohumeral muscular dystrophy. Previous studies have tested exercise at moderate intensity. No studies have so far investigated whether high-intensity-training (HIIT) exerci...

Clinical trials have in recent years demonstrated that aerobic exercise, are both effective and safe in patients with facioscapulohumeral muscular dystrophy. Previous studies have tested exercise at moderate intensity. No studies have so far investigated whether high-intensity-training (HIIT) exercise can increase fitness, or the training will cause muscle damage. However, we know that patients with facioscapulohumeral muscular dystrophy do not get increased muscle damage after a single exercise at high intensity. Investigators aim to investigate whether patients with facioscapulohumeral muscular disease may increase their fitness and improve their functioning in everyday life without muscle injury in a time-saving high intensity training. To investigate whether HIIT is safe and effective, three groups of participants are included. Two training groups, one group of patients and another with healthy matched subjects. The training is done on an ergometer-bike three times a week for 8 weeks. One weekly training will be supervised. The training consists of an interval training program (10-20-30). The third group is a none-training control group of patients. This group will undergo the same tests as the two training groups. To investigate wether participants would continue HIIT training after 8 weeks of supervised training, the two training groups, one group of patients and one group of healthy matched subjects, are tested after additional 8 weeks of home based optional training. To investigate wether patients with muscular dystrophy facioscapulohumeral will perform unsupervised HIIT training and whether it will be as effective as the supervised training, the control group of patients who did not train the first 8 weeks, is instructed to do home based HIIT for 8 weeks.

Inclusion Criterias

Diagnosed with Facioscapulohumeral muscular dystrophy or
healthy matched control, matched for age, gender, BMI and activity level.
Diagnosed with Facioscapulohumeral muscular dystrophy or
healthy matched control, matched for age, gender, BMI and activity level.

Exclusion Criterias

Pregnant or breastfeeding women.
Physical or mental condition, which prevent participating in the study protocol.
More than 1 hour cardiac exercise weekly before inclusion.
...
Pregnant or breastfeeding women.
Physical or mental condition, which prevent participating in the study protocol.
More than 1 hour cardiac exercise weekly before inclusion.
Physical or mental condition, which could influence the results.
Participating in other studies, which could influence the results.

Locations

Copenhagen, DK-2100
Copenhagen, DK-2100

Tracking Information

NCT #
NCT02159963
Collaborators
Not Provided
Investigators
Not Provided