Racial and Aging Effects of Acute Antioxidant Supplementation
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
- Estimated Enrollment
- 88
Inclusion Criteria
- Without diagnosed atherosclerotic disease
- General Good health
- Do not use anti-inflammatory medication within last 2 weeks
- ...
- Without diagnosed atherosclerotic disease
- General Good health
- Do not use anti-inflammatory medication within last 2 weeks
- 18-35 or 55-75 years of age
- Do not use steroidal substances within past 2 weeks
- Participants on medications (not listed in the Exclusion Criteria) will take medication as normal on all days of study visits.
- Do not use antioxidant vitamin supplementation
- Without metabolic or inflammatory disease
Exclusion Criteria
- Bleeding disorder
- Bacterial, viral or upper respiratory infection within past 1 month
- Hyperlipidemia (total cholesterol >240 mg/dl)
- ...
- Bleeding disorder
- Bacterial, viral or upper respiratory infection within past 1 month
- Hyperlipidemia (total cholesterol >240 mg/dl)
- Anticoagulant medication
- Current smoker
- Blood pressure greater than 140/90 mmHg
- Inflammatory disease (rheumatoid arthritis, systemic lupus erythematosus, etc)
- Diabetes (fasting glucose >110 mg/dl)
- Pregnant women
- Diagnosed cardiac arrhythmia
- Diagnosed atherosclerotic heart disease
- Severe obesity (BMI>40 kg/m2)
Summary
- Conditions
- Healthy
- Type
- Interventional
- Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
Participation Requirements
- Age
- Between 18 years and 75 years
- Gender
- Both males and females
Description
The overall goal of this application is to investigate the effect of aging on how acute antioxidant supplementation affects decrements in arterial function observed in African Americans (AA). Additionally, this application will facilitate the applicant's emergence as an independent investigator in i...
The overall goal of this application is to investigate the effect of aging on how acute antioxidant supplementation affects decrements in arterial function observed in African Americans (AA). Additionally, this application will facilitate the applicant's emergence as an independent investigator in integrative clinical physiology. Oxidative stress (OS), contributes to hypertension, diabetes, heart failure, atherosclerosis, sepsis and aging. Increased OS leads to the development of endothelial dysfunction and subsequent development of cardiovascular disease through the inactivation of nitric oxide (NO) by superoxide (O2) and other free radicals. African Americans (AA) have increased OS and inflammation in vivo and in vitro, and have a lower serum concentration of most antioxidants. Endothelial cells of AAs have steady state NO/ O2/ONOO- balance that is close to redox state, which is a characteristic of endothelium impaired function disorders. Endothelium-derived NO is a vasodilator and inhibits monocyte adhesion and platelet activity and therefore is important in the maintenance of vascular homeostasis. These specific differences in OS could be a contributing mechanism to the high prevalence of cardiovascular disease, especially hypertension and heart failure, observed in AA. Aging causes increases in OS, endothelial dysfunction, and decreased arterial compliance, thus increasing the risk of cardiovascular disease. Acute supra-physiological dosages of antioxidants have been shown to transiently restore endothelial function in older adults and patients with coronary artery disease and hypertension by scavenging free radicals.However, it is unknown if acute antioxidant supplementation can diminish differences in vascular function between AA and Caucasians (CA). It is also unknown if acute antioxidant supplementation with known efficacy will differentially affect blood flow in AA vs CA during exercise.
Inclusion Criteria
- Without diagnosed atherosclerotic disease
- General Good health
- Do not use anti-inflammatory medication within last 2 weeks
- ...
- Without diagnosed atherosclerotic disease
- General Good health
- Do not use anti-inflammatory medication within last 2 weeks
- 18-35 or 55-75 years of age
- Do not use steroidal substances within past 2 weeks
- Participants on medications (not listed in the Exclusion Criteria) will take medication as normal on all days of study visits.
- Do not use antioxidant vitamin supplementation
- Without metabolic or inflammatory disease
Exclusion Criteria
- Bleeding disorder
- Bacterial, viral or upper respiratory infection within past 1 month
- Hyperlipidemia (total cholesterol >240 mg/dl)
- ...
- Bleeding disorder
- Bacterial, viral or upper respiratory infection within past 1 month
- Hyperlipidemia (total cholesterol >240 mg/dl)
- Anticoagulant medication
- Current smoker
- Blood pressure greater than 140/90 mmHg
- Inflammatory disease (rheumatoid arthritis, systemic lupus erythematosus, etc)
- Diabetes (fasting glucose >110 mg/dl)
- Pregnant women
- Diagnosed cardiac arrhythmia
- Diagnosed atherosclerotic heart disease
- Severe obesity (BMI>40 kg/m2)
Tracking Information
- NCT #
- NCT02157207
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Bo Fernhall, Ph.D. University of Illinois at Chicago
- Bo Fernhall, Ph.D. University of Illinois at Chicago
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