Recruitment

Recruitment Status
Completed
Estimated Enrollment
88

Inclusion Criterias

General Good health
Without diagnosed atherosclerotic disease
Do not use steroidal substances within past 2 weeks
...
General Good health
Without diagnosed atherosclerotic disease
Do not use steroidal substances within past 2 weeks
Participants on medications (not listed in the Exclusion Criteria) will take medication as normal on all days of study visits.
Do not use anti-inflammatory medication within last 2 weeks
18-35 or 55-75 years of age
Without metabolic or inflammatory disease
Do not use antioxidant vitamin supplementation

Exclusion Criterias

Inflammatory disease (rheumatoid arthritis, systemic lupus erythematosus, etc)
Current smoker
Severe obesity (BMI>40 kg/m2)
...
Inflammatory disease (rheumatoid arthritis, systemic lupus erythematosus, etc)
Current smoker
Severe obesity (BMI>40 kg/m2)
Hyperlipidemia (total cholesterol >240 mg/dl)
Blood pressure greater than 140/90 mmHg
Diagnosed atherosclerotic heart disease
Bleeding disorder
Diabetes (fasting glucose >110 mg/dl)
Pregnant women
Diagnosed cardiac arrhythmia
Bacterial, viral or upper respiratory infection within past 1 month
Anticoagulant medication

Summary

Conditions
Healthy
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Crossover Assignment
  • Masking: Double (Participant, Investigator)
  • Primary Purpose: Prevention

Participation Requirements

Age
Between 18 years and 75 years
Gender
Both males and females

Description

The overall goal of this application is to investigate the effect of aging on how acute antioxidant supplementation affects decrements in arterial function observed in African Americans (AA). Additionally, this application will facilitate the applicant's emergence as an independent investigator in i...

The overall goal of this application is to investigate the effect of aging on how acute antioxidant supplementation affects decrements in arterial function observed in African Americans (AA). Additionally, this application will facilitate the applicant's emergence as an independent investigator in integrative clinical physiology. Oxidative stress (OS), contributes to hypertension, diabetes, heart failure, atherosclerosis, sepsis and aging. Increased OS leads to the development of endothelial dysfunction and subsequent development of cardiovascular disease through the inactivation of nitric oxide (NO) by superoxide (O2) and other free radicals. African Americans (AA) have increased OS and inflammation in vivo and in vitro, and have a lower serum concentration of most antioxidants. Endothelial cells of AAs have steady state NO/ O2/ONOO- balance that is close to redox state, which is a characteristic of endothelium impaired function disorders. Endothelium-derived NO is a vasodilator and inhibits monocyte adhesion and platelet activity and therefore is important in the maintenance of vascular homeostasis. These specific differences in OS could be a contributing mechanism to the high prevalence of cardiovascular disease, especially hypertension and heart failure, observed in AA. Aging causes increases in OS, endothelial dysfunction, and decreased arterial compliance, thus increasing the risk of cardiovascular disease. Acute supra-physiological dosages of antioxidants have been shown to transiently restore endothelial function in older adults and patients with coronary artery disease and hypertension by scavenging free radicals.However, it is unknown if acute antioxidant supplementation can diminish differences in vascular function between AA and Caucasians (CA). It is also unknown if acute antioxidant supplementation with known efficacy will differentially affect blood flow in AA vs CA during exercise.

Inclusion Criterias

General Good health
Without diagnosed atherosclerotic disease
Do not use steroidal substances within past 2 weeks
...
General Good health
Without diagnosed atherosclerotic disease
Do not use steroidal substances within past 2 weeks
Participants on medications (not listed in the Exclusion Criteria) will take medication as normal on all days of study visits.
Do not use anti-inflammatory medication within last 2 weeks
18-35 or 55-75 years of age
Without metabolic or inflammatory disease
Do not use antioxidant vitamin supplementation

Exclusion Criterias

Inflammatory disease (rheumatoid arthritis, systemic lupus erythematosus, etc)
Current smoker
Severe obesity (BMI>40 kg/m2)
...
Inflammatory disease (rheumatoid arthritis, systemic lupus erythematosus, etc)
Current smoker
Severe obesity (BMI>40 kg/m2)
Hyperlipidemia (total cholesterol >240 mg/dl)
Blood pressure greater than 140/90 mmHg
Diagnosed atherosclerotic heart disease
Bleeding disorder
Diabetes (fasting glucose >110 mg/dl)
Pregnant women
Diagnosed cardiac arrhythmia
Bacterial, viral or upper respiratory infection within past 1 month
Anticoagulant medication

Locations

Chicago, Illinois, 60612
Chicago, Illinois, 60612

Tracking Information

NCT #
NCT02157207
Collaborators
Not Provided
Investigators
  • Principal Investigator: Bo Fernhall, Ph.D. University of Illinois at Chicago
  • Bo Fernhall, Ph.D. University of Illinois at Chicago