Recruitment

Recruitment Status
Completed
Estimated Enrollment
47

Inclusion Criterias

Women must agree not to donate eggs (ova, oocytes) from Screening until at least 6 months after the final dose of study medication
Severity of disease: subjects who conform to the current severity classification for Global Initiative for Chronic Obstructive Lung Disease (GOLD, 2014) Grade II/III
Be able to produce an acceptable induced sputum sample at the Screening visit.
...
Women must agree not to donate eggs (ova, oocytes) from Screening until at least 6 months after the final dose of study medication
Severity of disease: subjects who conform to the current severity classification for Global Initiative for Chronic Obstructive Lung Disease (GOLD, 2014) Grade II/III
Be able to produce an acceptable induced sputum sample at the Screening visit.
Have a 12 lead ECG recording consistent with normal cardiac function at the Screening visit and pre-dose Day 1
Women of non-childbearing potential must be either amenorrhoeic >1 year with an appropriate clinical profile or permanently sterilised
Be a man or a woman of non-child-bearing potential aged 40 to 75 years
On a background therapy of inhaled steroid with or without the addition of long-acting bronchodilators (either long-acting beta agonists [LABAs] or long-acting muscarinic antagonists [LAMAs]).
Chronic obstructive pulmonary disease diagnosis with symptoms compatible with COPD for at least 1 year before Screening.
A current or previous smoker with a smoking history of ≥10 pack years.
Men must be willing to use one form of contraception (with documented failure rate less than 1%) and agree not to donate sperm from Screening to 90 days post last dose of study agent
Sign an informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study.
Capable of complying with all study restrictions and procedures including ability to use the study inhaler correctly.

Exclusion Criterias

Chronic liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
Received an experimental drug or used an experimental medical device within 3 months or within a period less than five times the drug's half-life, whichever is longer, before the first dose of the study drug is scheduled.
Previous lung resection or lung reduction surgery.
...
Chronic liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
Received an experimental drug or used an experimental medical device within 3 months or within a period less than five times the drug's half-life, whichever is longer, before the first dose of the study drug is scheduled.
Previous lung resection or lung reduction surgery.
History of clinically significant allergies that, in the opinion of the Investigator would contraindicate their participation.
Requires routine treatment for COPD using one (or more) of the therapies listed in the protocol within the 6 weeks before Screening.
Other respiratory disorders: subjects with a history of asthma, active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, lung fibrosis or other chronic pulmonary diseases.
Upper or lower respiratory tract infection, including exacerbation of COPD, requiring augmentation of therapy within 6 weeks of Screening.
Vital sign assessments outside the following ranges: for inclusion blood pressure (after the subject is supine for 10 minutes) must be between 100 and 160 mmHg systolic, inclusive, and between 55 and 100 mmHg diastolic; heart rate must be between 40-100 bpm. These criteria must be met at Screening, Day -1 and pre-dose on Day 1.
A history of life-threatening COPD including respiratory arrest, intensive care unit admission and/or requiring intubation.
Any other reason that the Investigator considers makes the subject unsuitable to participate.
Unable or unwilling to undergo multiple venepuncture procedures or the subject has poor access to veins suitable for cannulation.
A disclosed history or one known to the Investigator, of significant non-compliance in previous investigational studies or with prescribed medications.
A chest X-ray at Screening (or within 6 months prior to the Screening visit) showing abnormalities, which in the opinion of the Investigator are clinically significant and unrelated to COPD.
Liver function test results (ALT, aspartate amino transferase and gamma glutamyl transferase) >2 x ULN (upper limit of normal) at Screening or on Day -1.
The subject is unable or unwilling to comply fully with the study protocol.
Has had major surgery, (requiring general anaesthesia) within 6 weeks before the Screening visit, or will not have fully recovered from surgery, or has planned surgery from Screening through to the end of the study. Note: subjects with planned surgical procedures to be conducted under local anaesthesia may participate.
Evidence of cor pulmonale, clinically significant pulmonary hypertension or chronic use of oxygen.
If a woman, has a positive serum pregnancy test at Screening.
The subject is mentally or legally incapacitated.
A history of more than one hospitalisation for COPD in the 2 years before Screening.
Known allergy to the study drug or any of the excipients of the formulation or has previously been exposed to RV1729.
Positive test for human immunodeficiency virus (HIV) 1 and 2 antibodies, hepatitis B virus (HBV) infection or hepatitis C antibodies.
A history of chronic disease including, but not limited to, unstable or uncontrolled hypertension (or been diagnosed with hypertension in the 6 months before Screening), sleep apnoea, cardiovascular, endocrine, neurological, hepatic, gastrointestinal, renal, haematological, urological, immunological or ophthalmic diseases that the Investigator believes are clinically significant e.g., unstable and could impact subject safety by participation in the study.
History of regular alcohol consumption within 6 months of the study defined as an average weekly intake of >21 units for males, or >14 units for females.
Donated blood or blood products or had substantial loss of blood (more than 500 mL) within 3 months before the first administration of study drug or intention to donate blood or blood products during the study.
Have a clinical abnormality or laboratory parameters outside the reference range at Screening or Day -1.
Definite or suspected history of drug or alcohol abuse within the previous 5 years.
Positive test for alcohol or drugs of abuse, including cannabinoids, alcohol, opiates, cocaine, amphetamines, benzodiazepines or barbiturates at Screening or on Day -1 or Day 1.
Employee of the Investigator or study centre, with direct involvement in the proposed study or other studies under the direction of that Investigator or study centre, as well as family members of the employees or the Investigator.

Summary

Conditions
Chronic Obstructive Pulmonary Disease
Type
Interventional
Phase
Phase 1
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Triple (Participant, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 40 years and 75 years
Gender
Both males and females

Inclusion Criterias

Women must agree not to donate eggs (ova, oocytes) from Screening until at least 6 months after the final dose of study medication
Severity of disease: subjects who conform to the current severity classification for Global Initiative for Chronic Obstructive Lung Disease (GOLD, 2014) Grade II/III
Be able to produce an acceptable induced sputum sample at the Screening visit.
...
Women must agree not to donate eggs (ova, oocytes) from Screening until at least 6 months after the final dose of study medication
Severity of disease: subjects who conform to the current severity classification for Global Initiative for Chronic Obstructive Lung Disease (GOLD, 2014) Grade II/III
Be able to produce an acceptable induced sputum sample at the Screening visit.
Have a 12 lead ECG recording consistent with normal cardiac function at the Screening visit and pre-dose Day 1
Women of non-childbearing potential must be either amenorrhoeic >1 year with an appropriate clinical profile or permanently sterilised
Be a man or a woman of non-child-bearing potential aged 40 to 75 years
On a background therapy of inhaled steroid with or without the addition of long-acting bronchodilators (either long-acting beta agonists [LABAs] or long-acting muscarinic antagonists [LAMAs]).
Chronic obstructive pulmonary disease diagnosis with symptoms compatible with COPD for at least 1 year before Screening.
A current or previous smoker with a smoking history of ≥10 pack years.
Men must be willing to use one form of contraception (with documented failure rate less than 1%) and agree not to donate sperm from Screening to 90 days post last dose of study agent
Sign an informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study.
Capable of complying with all study restrictions and procedures including ability to use the study inhaler correctly.

Exclusion Criterias

Chronic liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
Received an experimental drug or used an experimental medical device within 3 months or within a period less than five times the drug's half-life, whichever is longer, before the first dose of the study drug is scheduled.
Previous lung resection or lung reduction surgery.
...
Chronic liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
Received an experimental drug or used an experimental medical device within 3 months or within a period less than five times the drug's half-life, whichever is longer, before the first dose of the study drug is scheduled.
Previous lung resection or lung reduction surgery.
History of clinically significant allergies that, in the opinion of the Investigator would contraindicate their participation.
Requires routine treatment for COPD using one (or more) of the therapies listed in the protocol within the 6 weeks before Screening.
Other respiratory disorders: subjects with a history of asthma, active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, lung fibrosis or other chronic pulmonary diseases.
Upper or lower respiratory tract infection, including exacerbation of COPD, requiring augmentation of therapy within 6 weeks of Screening.
Vital sign assessments outside the following ranges: for inclusion blood pressure (after the subject is supine for 10 minutes) must be between 100 and 160 mmHg systolic, inclusive, and between 55 and 100 mmHg diastolic; heart rate must be between 40-100 bpm. These criteria must be met at Screening, Day -1 and pre-dose on Day 1.
A history of life-threatening COPD including respiratory arrest, intensive care unit admission and/or requiring intubation.
Any other reason that the Investigator considers makes the subject unsuitable to participate.
Unable or unwilling to undergo multiple venepuncture procedures or the subject has poor access to veins suitable for cannulation.
A disclosed history or one known to the Investigator, of significant non-compliance in previous investigational studies or with prescribed medications.
A chest X-ray at Screening (or within 6 months prior to the Screening visit) showing abnormalities, which in the opinion of the Investigator are clinically significant and unrelated to COPD.
Liver function test results (ALT, aspartate amino transferase and gamma glutamyl transferase) >2 x ULN (upper limit of normal) at Screening or on Day -1.
The subject is unable or unwilling to comply fully with the study protocol.
Has had major surgery, (requiring general anaesthesia) within 6 weeks before the Screening visit, or will not have fully recovered from surgery, or has planned surgery from Screening through to the end of the study. Note: subjects with planned surgical procedures to be conducted under local anaesthesia may participate.
Evidence of cor pulmonale, clinically significant pulmonary hypertension or chronic use of oxygen.
If a woman, has a positive serum pregnancy test at Screening.
The subject is mentally or legally incapacitated.
A history of more than one hospitalisation for COPD in the 2 years before Screening.
Known allergy to the study drug or any of the excipients of the formulation or has previously been exposed to RV1729.
Positive test for human immunodeficiency virus (HIV) 1 and 2 antibodies, hepatitis B virus (HBV) infection or hepatitis C antibodies.
A history of chronic disease including, but not limited to, unstable or uncontrolled hypertension (or been diagnosed with hypertension in the 6 months before Screening), sleep apnoea, cardiovascular, endocrine, neurological, hepatic, gastrointestinal, renal, haematological, urological, immunological or ophthalmic diseases that the Investigator believes are clinically significant e.g., unstable and could impact subject safety by participation in the study.
History of regular alcohol consumption within 6 months of the study defined as an average weekly intake of >21 units for males, or >14 units for females.
Donated blood or blood products or had substantial loss of blood (more than 500 mL) within 3 months before the first administration of study drug or intention to donate blood or blood products during the study.
Have a clinical abnormality or laboratory parameters outside the reference range at Screening or Day -1.
Definite or suspected history of drug or alcohol abuse within the previous 5 years.
Positive test for alcohol or drugs of abuse, including cannabinoids, alcohol, opiates, cocaine, amphetamines, benzodiazepines or barbiturates at Screening or on Day -1 or Day 1.
Employee of the Investigator or study centre, with direct involvement in the proposed study or other studies under the direction of that Investigator or study centre, as well as family members of the employees or the Investigator.

Locations

Manchester, M23 9QZ
Belfast, BT9 6AD
Manchester, M23 9QZ
Belfast, BT9 6AD

Tracking Information

NCT #
NCT02140346
Collaborators
Not Provided
Investigators
Study Director: Liza O'Dowd, MD Sponsor GmbH