Aromatase Inhibitor Growth Study: Letrozole vs. Anastrozole
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
- Estimated Enrollment
- 80
Inclusion Criteria
- Predicted adult height (based on bone age) more than 10 cm below target height (mid parental height)
- Current height less than 5th percentile AND/OR
- Evidence of puberty: physical signs and serum luteinizing hormone > 0.3 IU/L and testosterone > 15 ng/dl
- Predicted adult height (based on bone age) more than 10 cm below target height (mid parental height)
- Current height less than 5th percentile AND/OR
- Evidence of puberty: physical signs and serum luteinizing hormone > 0.3 IU/L and testosterone > 15 ng/dl
Exclusion Criteria
- Bone age reading more than 14.0 years
- Follicle stimulating hormone > 20 IU/L
- Bone age reading more than 14.0 years
- Follicle stimulating hormone > 20 IU/L
Summary
- Conditions
- Short Stature
- Type
- Interventional
- Phase
- Phase 4
- Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
Participation Requirements
- Age
- Between 10 years and 17 years
- Gender
- Only males
Inclusion Criteria
- Predicted adult height (based on bone age) more than 10 cm below target height (mid parental height)
- Current height less than 5th percentile AND/OR
- Evidence of puberty: physical signs and serum luteinizing hormone > 0.3 IU/L and testosterone > 15 ng/dl
- Predicted adult height (based on bone age) more than 10 cm below target height (mid parental height)
- Current height less than 5th percentile AND/OR
- Evidence of puberty: physical signs and serum luteinizing hormone > 0.3 IU/L and testosterone > 15 ng/dl
Exclusion Criteria
- Bone age reading more than 14.0 years
- Follicle stimulating hormone > 20 IU/L
- Bone age reading more than 14.0 years
- Follicle stimulating hormone > 20 IU/L
Tracking Information
- NCT #
- NCT02137538
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: E Kirk Neely, MD Stanford University
- E Kirk Neely, MD Stanford University Principal Investigator: Laura K Bachrach, MD Stanford University Principal Investigator: Walter A Zegarra, MD Stanford University
Get Well Soon