Unexpected Pharmacokinetics of Vancomycin in Patients With Severe Acute Pancreatitis Compared With Pneumonia
Last updated on April 2022Recruitment
- Recruitment Status
- Unknown status
Inclusion Criteria
- age 18-85years old
- vancomycin use ≥ 3days
- age 18-85years old
- vancomycin use ≥ 3days
Exclusion Criteria
- vancomycin use < 3days
- age <18years old or >85 years old
- vancomycin use < 3days
- age <18years old or >85 years old
Summary
- Conditions
- Arbitrary Restriction Polymorphism 1
- Type
- Observational
- Design
- Observational Model: Case-Control
- Time Perspective: Retrospective
Participation Requirements
- Age
- Between 18 years and 85 years
- Gender
- Both males and females
Description
The purpose of this study was to evaluate the influence of severe acute pancreatitis on the serum level of vancomycin, a glycopeptide antibacterial agent. After reviewing more than 6000 clinical charts of patients who received vancomycin therapy and whose serum vancomycin level was monitored between...
The purpose of this study was to evaluate the influence of severe acute pancreatitis on the serum level of vancomycin, a glycopeptide antibacterial agent. After reviewing more than 6000 clinical charts of patients who received vancomycin therapy and whose serum vancomycin level was monitored between January 2010 and December 2013, we identified 212 patients who also had diagnosed as severe acute pancreatitis (SAP group), and 98 patients who also had diagnosed as pneumonia (pneumonia group) at that time. The fluorescence polarization immunoassay method was used to measure vancomycin serum trough concentrations in these patients 30 min before the next administration. Using these measurements, we calculated the pharmacokinetic parameters using the Bayesian estimator.
Inclusion Criteria
- age 18-85years old
- vancomycin use ≥ 3days
- age 18-85years old
- vancomycin use ≥ 3days
Exclusion Criteria
- vancomycin use < 3days
- age <18years old or >85 years old
- vancomycin use < 3days
- age <18years old or >85 years old
Tracking Information
- NCT #
- NCT02134665
- Collaborators
- Not Provided
- Investigators
- Study Director: Wan-Hua Yang, Prof. Ruijin Hospital