Effects of Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
Inclusion Criteria
- Admitted for septic shock were considered eligible if they had no life-threatening systemic disease (ASA groups 1~3)
- All patients(age≧18y)
- Admitted for septic shock were considered eligible if they had no life-threatening systemic disease (ASA groups 1~3)
- All patients(age≧18y)
Exclusion Criteria
- Disseminated cancer
- Secondary cancers
- Inflammatory bowel disease, or diseases hindering epidural analgesia
- ...
- Disseminated cancer
- Secondary cancers
- Inflammatory bowel disease, or diseases hindering epidural analgesia
- Lactation
- Mental disorders
Summary
- Conditions
- Coagulation Dysfunction in Septic Shock
- Hemodynamic Improvement Induced by Hydrocortisone
- Type
- Interventional
- Phase
- Phase 3
- Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 78 years
- Gender
- Both males and females
Description
Patients were randomized to receive either low-dose hydrocortisone or matching placebo.Severity of coagulopathy was estimated using ISTH DIC score. We determined the complications and mortality in two groups, and analyzed the relationship between hydrocortisone and coagulopathy.
Patients were randomized to receive either low-dose hydrocortisone or matching placebo.Severity of coagulopathy was estimated using ISTH DIC score. We determined the complications and mortality in two groups, and analyzed the relationship between hydrocortisone and coagulopathy.
Inclusion Criteria
- Admitted for septic shock were considered eligible if they had no life-threatening systemic disease (ASA groups 1~3)
- All patients(age≧18y)
- Admitted for septic shock were considered eligible if they had no life-threatening systemic disease (ASA groups 1~3)
- All patients(age≧18y)
Exclusion Criteria
- Disseminated cancer
- Secondary cancers
- Inflammatory bowel disease, or diseases hindering epidural analgesia
- ...
- Disseminated cancer
- Secondary cancers
- Inflammatory bowel disease, or diseases hindering epidural analgesia
- Lactation
- Mental disorders
Tracking Information
- NCT #
- NCT02114710
- Collaborators
- Not Provided
- Investigators
- Not Provided
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