Recruitment

Recruitment Status
Completed
Estimated Enrollment
90

Inclusion Criteria

Waist circumference >80.0 cm for women and >94.0 cm for men
Plasma concentration of triglycerides >1.70 mmol / L
Men and women age between 18 and 65 years
...
Waist circumference >80.0 cm for women and >94.0 cm for men
Plasma concentration of triglycerides >1.70 mmol / L
Men and women age between 18 and 65 years
Stable weight for 6 months before the start of the study (+/- 5lbs)

Exclusion Criteria

Food allergies and aversions to any food in the composition of experimental menus
Smoking
History of CVD, type 2 diabetes or dyslipidaemia monogenic
...
Food allergies and aversions to any food in the composition of experimental menus
Smoking
History of CVD, type 2 diabetes or dyslipidaemia monogenic
Endocrine disorders
Subject with a calculated Framingham risk of cardiovascular disease (CVD) > 20%
Subjects with special dietary habits (e.g. vegetarianism)
Men or women aged under 18 years or over 65 years
Lipid lowering medications or hypertension medications

Summary

Conditions
Metabolic Syndrome
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Crossover Assignment
  • Masking: Single (Outcomes Assessor)
  • Primary Purpose: Prevention

Participation Requirements

Age
Between 18 years and 65 years
Gender
Both males and females

Description

This is a multi-center randomized crossover controlled feeding study. Briefly, adult men and women will be recruited in the Quebec City and Winnipeg metropolitan area through the media (newspaper, radio), local lipid clinics and mailing lists (n=90). Participants will be randomized to a series of 5 ...

This is a multi-center randomized crossover controlled feeding study. Briefly, adult men and women will be recruited in the Quebec City and Winnipeg metropolitan area through the media (newspaper, radio), local lipid clinics and mailing lists (n=90). Participants will be randomized to a series of 5 experimental diets of 4 weeks each: 1- Cheese diet, 2- Butter diet, 3- Carbohydrate (CHO) diet, 4- MUFA diet, 5- PUFA diet. Usual energy intake will be estimated at the beginning of the study using validated tools. Experimental diets will be provided as part of a full feeding protocol under carefully controlled isocaloric conditions to maintain body weight constant. All meals and foods will be provided to participants so that control for energy and macronutrient intake will be optimized. The breakfast meal will represent approximately 30% of the daily energy intake whereas the lunch and dinner meals each will provide 35% of daily energy intake. Participants will be instructed to consume their entire meals. A seven-day cyclic menu will be used. The diets will be separated by washout periods of 4 weeks. Blood samples will be collected on two consecutive days before and after each dietary phase. The mean of the two consecutive measurements will be used in the analyses.

Inclusion Criteria

Waist circumference >80.0 cm for women and >94.0 cm for men
Plasma concentration of triglycerides >1.70 mmol / L
Men and women age between 18 and 65 years
...
Waist circumference >80.0 cm for women and >94.0 cm for men
Plasma concentration of triglycerides >1.70 mmol / L
Men and women age between 18 and 65 years
Stable weight for 6 months before the start of the study (+/- 5lbs)

Exclusion Criteria

Food allergies and aversions to any food in the composition of experimental menus
Smoking
History of CVD, type 2 diabetes or dyslipidaemia monogenic
...
Food allergies and aversions to any food in the composition of experimental menus
Smoking
History of CVD, type 2 diabetes or dyslipidaemia monogenic
Endocrine disorders
Subject with a calculated Framingham risk of cardiovascular disease (CVD) > 20%
Subjects with special dietary habits (e.g. vegetarianism)
Men or women aged under 18 years or over 65 years
Lipid lowering medications or hypertension medications

Locations

Winnipeg, Manitoba, R3T 6C5
Quebec, G1V 0A6
Winnipeg, Manitoba, R3T 6C5
Quebec, G1V 0A6

Tracking Information

NCT #
NCT02106208
Collaborators
  • Agriculture and Agri-Food Canada
  • Dairy Farmers of Canada
Investigators
  • Principal Investigator: Benoît Lamarche, PhD Laval University
  • Benoît Lamarche, PhD Laval University