Recruitment

Recruitment Status
Recruiting

Exclusion Criterias

Respiratory tract infection within the past 4 weeks.
Pregnancy.
An improvement in FEV1 of more than 12% following 4 puffs of albuterol.
...
Respiratory tract infection within the past 4 weeks.
Pregnancy.
An improvement in FEV1 of more than 12% following 4 puffs of albuterol.
Smoking history > 10 pack years if ≥30 years of age, or smoking history > 5 pack years if <30 years of age, or any smoking within the past year.
A history suggestive of allergic rhinitis, eczema or chronic sinusitis.
History of chronic diseases that affect the lungs.
History of premature birth (<35 weeks).

Summary

Conditions
Asthma
Type
Observational
Design
  • Observational Model: Cohort
  • Time Perspective: Cross-Sectional

Participation Requirements

Age
Between 18 years and 65 years
Gender
Both males and females

Description

Asthma is a heterogeneous disease characterized by airway hyperreactivity and chronic airway inflammation. Published literature from the last few years has shown that asthma does not behave like a single disease but is more of a syndrome with vast heterogeneity in pathogenesis, severity, and treatme...

Asthma is a heterogeneous disease characterized by airway hyperreactivity and chronic airway inflammation. Published literature from the last few years has shown that asthma does not behave like a single disease but is more of a syndrome with vast heterogeneity in pathogenesis, severity, and treatment response. Various clinical phenotypes and endotypes have been described that advance our understanding of these differences and the mechanisms underlying them. We propose there is a subgroup of asthmatic patients that have sputum with abnormal biophysical properties. Healthy airway mucus is composed of a lightly cross-linked gel that is easily transported by the mucociliary apparatus, coughed and expectorated or swallowed. Pathologic mucus has, in contrast, abnormally high elasticity. This is due to a more cross linked structure which gives the sputum the properties of solid and makes sputum difficult to mobilize. Increased sputum elasticity makes expectoration of sputum more difficult and leads to airflow obstruction. Pathologic mucus contributes to airflow obstruction and airway infection in multiple lung diseases, including asthma. Mucus plugs are a particular problem in asthmatic patients with allergic bronchopulmonary aspergillosis (ABPA)The identification of phenotype of severe asthma with pathologic mucus contributing to disease severity may change how we think about severe asthma, moving towards therapies targeting mucus clearance such as in other conditions such as cystic fibrosis. Pathologic mucus in severe asthma is characterized by cellular inflammation, high concentrations of mucins and DNA polymers. Knowledge of specific cellular and biochemical constituents of pathologic mucus in severe asthma can guide targeted mucolytic treatment with n-acetylcysteine, rhDNAse, or novel mucolytic agents. As part of the Severe Asthma Research Program (SARP), UCSF is in a unique position to recruit a large number of severe asthmatic subjects within which we expect a portion will demonstrate high sputum elasticity. We will also through CAESAR recruit additional subjects with moderate to severe airflow obstruction. We will perform rheological measurement on all subjects that are recruited to our site and from this identify a group of asthmatic cases that have an elastic modulus of ≥1 or <1 and compare properties of sputum from these subjects to healthy controls.

Exclusion Criterias

Respiratory tract infection within the past 4 weeks.
Pregnancy.
An improvement in FEV1 of more than 12% following 4 puffs of albuterol.
...
Respiratory tract infection within the past 4 weeks.
Pregnancy.
An improvement in FEV1 of more than 12% following 4 puffs of albuterol.
Smoking history > 10 pack years if ≥30 years of age, or smoking history > 5 pack years if <30 years of age, or any smoking within the past year.
A history suggestive of allergic rhinitis, eczema or chronic sinusitis.
History of chronic diseases that affect the lungs.
History of premature birth (<35 weeks).

Locations

San Francisco, California, 94143
San Francisco, California, 94143

Tracking Information

NCT #
NCT02103348
Collaborators
Not Provided
Investigators
  • Principal Investigator: John V Fahy, M.D. M.SC. University of California, San Francisco
  • John V Fahy, M.D. M.SC. University of California, San Francisco