Recruitment

Recruitment Status
Completed
Estimated Enrollment
20

Inclusion Criteria

Consume 200-500 mg caffeine daily
Willing and capable of signing the informed consent
Willing to and able to have MRIs
...
Consume 200-500 mg caffeine daily
Willing and capable of signing the informed consent
Willing to and able to have MRIs
Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
Willing to abstain from caffeine for 16 hours before each testing session

Exclusion Criteria

Color blindness
peripheral vascular disease
attention deficit hyperactivity disorder (ADHD)
...
Color blindness
peripheral vascular disease
attention deficit hyperactivity disorder (ADHD)
depression that has not been on a stable medical treatment for at least 4 weeks
migraines
diabetes
Pregnancy
Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
hypertension
active neurological dysfunction (such as a major Axis I psychopathology, Alzheimer's disease, Parkinson's disease, prior history of stroke, epilepsy, or serious central nervous system (CNS) trauma)
taking vasoactive medications (such as anti-hypertensive medications)
Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat

Summary

Conditions
Caffeine
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Crossover Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Basic Science

Participation Requirements

Age
Between 18 years and 55 years
Gender
Both males and females

Inclusion Criteria

Consume 200-500 mg caffeine daily
Willing and capable of signing the informed consent
Willing to and able to have MRIs
...
Consume 200-500 mg caffeine daily
Willing and capable of signing the informed consent
Willing to and able to have MRIs
Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
Willing to abstain from caffeine for 16 hours before each testing session

Exclusion Criteria

Color blindness
peripheral vascular disease
attention deficit hyperactivity disorder (ADHD)
...
Color blindness
peripheral vascular disease
attention deficit hyperactivity disorder (ADHD)
depression that has not been on a stable medical treatment for at least 4 weeks
migraines
diabetes
Pregnancy
Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
hypertension
active neurological dysfunction (such as a major Axis I psychopathology, Alzheimer's disease, Parkinson's disease, prior history of stroke, epilepsy, or serious central nervous system (CNS) trauma)
taking vasoactive medications (such as anti-hypertensive medications)
Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat

Tracking Information

NCT #
NCT02080845
Collaborators
The Hershey Company
Investigators
  • Principal Investigator: Paul J Laurient, MD, PhD Wake Forest University Health Sciences
  • Paul J Laurient, MD, PhD Wake Forest University Health Sciences