Recruitment

Recruitment Status
Completed
Estimated Enrollment
20

Inclusion Criteria

Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
Willing to and able to have MRIs
Consume 200-500 mg caffeine daily
...
Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
Willing to and able to have MRIs
Consume 200-500 mg caffeine daily
Willing and capable of signing the informed consent
Willing to abstain from caffeine for 16 hours before each testing session

Exclusion Criteria

hypertension
Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
active neurological dysfunction (such as a major Axis I psychopathology, Alzheimer's disease, Parkinson's disease, prior history of stroke, epilepsy, or serious central nervous system (CNS) trauma)
...
hypertension
Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
active neurological dysfunction (such as a major Axis I psychopathology, Alzheimer's disease, Parkinson's disease, prior history of stroke, epilepsy, or serious central nervous system (CNS) trauma)
peripheral vascular disease
diabetes
Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat
Color blindness
depression that has not been on a stable medical treatment for at least 4 weeks
migraines
Pregnancy
attention deficit hyperactivity disorder (ADHD)
taking vasoactive medications (such as anti-hypertensive medications)

Summary

Conditions
Caffeine
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Crossover Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Basic Science

Participation Requirements

Age
Between 18 years and 55 years
Gender
Both males and females

Inclusion Criteria

Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
Willing to and able to have MRIs
Consume 200-500 mg caffeine daily
...
Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
Willing to and able to have MRIs
Consume 200-500 mg caffeine daily
Willing and capable of signing the informed consent
Willing to abstain from caffeine for 16 hours before each testing session

Exclusion Criteria

hypertension
Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
active neurological dysfunction (such as a major Axis I psychopathology, Alzheimer's disease, Parkinson's disease, prior history of stroke, epilepsy, or serious central nervous system (CNS) trauma)
...
hypertension
Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
active neurological dysfunction (such as a major Axis I psychopathology, Alzheimer's disease, Parkinson's disease, prior history of stroke, epilepsy, or serious central nervous system (CNS) trauma)
peripheral vascular disease
diabetes
Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat
Color blindness
depression that has not been on a stable medical treatment for at least 4 weeks
migraines
Pregnancy
attention deficit hyperactivity disorder (ADHD)
taking vasoactive medications (such as anti-hypertensive medications)

Tracking Information

NCT #
NCT02080845
Collaborators
The Hershey Company
Investigators
  • Principal Investigator: Paul J Laurient, MD, PhD Wake Forest University Health Sciences
  • Paul J Laurient, MD, PhD Wake Forest University Health Sciences