Effects of a Cocoa Shot on the Human Brain 2
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
- Estimated Enrollment
- 20
Inclusion Criteria
- Willing to and able to have MRIs
- Willing to abstain from caffeine for 16 hours before each testing session
- Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
- ...
- Willing to and able to have MRIs
- Willing to abstain from caffeine for 16 hours before each testing session
- Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
- Consume 200-500 mg caffeine daily
- Willing and capable of signing the informed consent
Exclusion Criteria
- hypertension
- Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
- Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat
- ...
- hypertension
- Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
- Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat
- active neurological dysfunction (such as a major Axis I psychopathology, Alzheimer's disease, Parkinson's disease, prior history of stroke, epilepsy, or serious central nervous system (CNS) trauma)
- Pregnancy
- diabetes
- migraines
- depression that has not been on a stable medical treatment for at least 4 weeks
- Color blindness
- peripheral vascular disease
- taking vasoactive medications (such as anti-hypertensive medications)
- attention deficit hyperactivity disorder (ADHD)
Summary
- Conditions
- Caffeine
- Type
- Interventional
- Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
Participation Requirements
- Age
- Between 18 years and 55 years
- Gender
- Both males and females
Inclusion Criteria
- Willing to and able to have MRIs
- Willing to abstain from caffeine for 16 hours before each testing session
- Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
- ...
- Willing to and able to have MRIs
- Willing to abstain from caffeine for 16 hours before each testing session
- Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
- Consume 200-500 mg caffeine daily
- Willing and capable of signing the informed consent
Exclusion Criteria
- hypertension
- Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
- Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat
- ...
- hypertension
- Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
- Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat
- active neurological dysfunction (such as a major Axis I psychopathology, Alzheimer's disease, Parkinson's disease, prior history of stroke, epilepsy, or serious central nervous system (CNS) trauma)
- Pregnancy
- diabetes
- migraines
- depression that has not been on a stable medical treatment for at least 4 weeks
- Color blindness
- peripheral vascular disease
- taking vasoactive medications (such as anti-hypertensive medications)
- attention deficit hyperactivity disorder (ADHD)
Tracking Information
- NCT #
- NCT02080845
- Collaborators
- The Hershey Company
- Investigators
- Principal Investigator: Paul J Laurient, MD, PhD Wake Forest University Health Sciences
- Paul J Laurient, MD, PhD Wake Forest University Health Sciences
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