Recruitment

Recruitment Status
Completed
Estimated Enrollment
20

Inclusion Criterias

Consume 200-500 mg caffeine daily
Willing to and able to have MRIs
Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
...
Consume 200-500 mg caffeine daily
Willing to and able to have MRIs
Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
Willing and capable of signing the informed consent
Willing to abstain from caffeine for 16 hours before each testing session

Exclusion Criterias

Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat
taking vasoactive medications (such as anti-hypertensive medications)
migraines
...
Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat
taking vasoactive medications (such as anti-hypertensive medications)
migraines
Color blindness
active neurological dysfunction (such as a major Axis I psychopathology, Alzheimer's disease, Parkinson's disease, prior history of stroke, epilepsy, or serious central nervous system (CNS) trauma)
Pregnancy
attention deficit hyperactivity disorder (ADHD)
diabetes
Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
peripheral vascular disease
hypertension
depression that has not been on a stable medical treatment for at least 4 weeks

Summary

Conditions
Caffeine
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Crossover Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Basic Science

Participation Requirements

Age
Between 18 years and 55 years
Gender
Both males and females

Inclusion Criterias

Consume 200-500 mg caffeine daily
Willing to and able to have MRIs
Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
...
Consume 200-500 mg caffeine daily
Willing to and able to have MRIs
Willing to attend 4 testing sessions that will take 4-6 hours each AND will be at least 10 days apart
Willing and capable of signing the informed consent
Willing to abstain from caffeine for 16 hours before each testing session

Exclusion Criterias

Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat
taking vasoactive medications (such as anti-hypertensive medications)
migraines
...
Allergy to chocolate, peanuts, tree nuts, egg, soy, milk, wheat
taking vasoactive medications (such as anti-hypertensive medications)
migraines
Color blindness
active neurological dysfunction (such as a major Axis I psychopathology, Alzheimer's disease, Parkinson's disease, prior history of stroke, epilepsy, or serious central nervous system (CNS) trauma)
Pregnancy
attention deficit hyperactivity disorder (ADHD)
diabetes
Individuals who are or potentially may be cognitively or psychologically impaired, or who otherwise have a limited capacity to provide consent
peripheral vascular disease
hypertension
depression that has not been on a stable medical treatment for at least 4 weeks

Locations

Winston-Salem, North Carolina, 27157
Winston-Salem, North Carolina, 27157

Tracking Information

NCT #
NCT02080845
Collaborators
The Hershey Company
Investigators
  • Principal Investigator: Paul J Laurient, MD, PhD Wake Forest University Health Sciences
  • Paul J Laurient, MD, PhD Wake Forest University Health Sciences