Recruitment

Recruitment Status
Completed
Estimated Enrollment
50

Inclusion Criterias

Healthy volunteers 25 to 55 years old.
Volunteers have a Body Mass Index (BMI), calculated from the ratio of height and weight, within a range of 18.5 to 35.
Willing to be medication and supplement free 2 weeks prior to beginning study, and throughout the study. All forms of birth control are okay.
Healthy volunteers 25 to 55 years old.
Volunteers have a Body Mass Index (BMI), calculated from the ratio of height and weight, within a range of 18.5 to 35.
Willing to be medication and supplement free 2 weeks prior to beginning study, and throughout the study. All forms of birth control are okay.

Exclusion Criterias

Any medical or surgical conditions which might significantly alter bupropion absorption (e.g., history of malabsorption, liver disease, gastric bypass surgery )
Alcohol dependence
Nicotine dependence
...
Any medical or surgical conditions which might significantly alter bupropion absorption (e.g., history of malabsorption, liver disease, gastric bypass surgery )
Alcohol dependence
Nicotine dependence
Individuals unwilling or unable to comply with the study protocol (e.g. unable to remain medication or supplement free during the study).
Individuals with a history of psychiatric or neurological illness, including seizure disorders
Pregnant or nursing women
Individuals unwilling or unable to take bupropion or have an allergy to bupropion

Summary

Conditions
Depression
Type
Interventional
Phase
Phase 4
Design
  • Allocation: Randomized
  • Intervention Model: Crossover Assignment
  • Masking: Single (Outcomes Assessor)
  • Primary Purpose: Basic Science

Participation Requirements

Age
Between 25 years and 55 years
Gender
Both males and females

Inclusion Criterias

Healthy volunteers 25 to 55 years old.
Volunteers have a Body Mass Index (BMI), calculated from the ratio of height and weight, within a range of 18.5 to 35.
Willing to be medication and supplement free 2 weeks prior to beginning study, and throughout the study. All forms of birth control are okay.
Healthy volunteers 25 to 55 years old.
Volunteers have a Body Mass Index (BMI), calculated from the ratio of height and weight, within a range of 18.5 to 35.
Willing to be medication and supplement free 2 weeks prior to beginning study, and throughout the study. All forms of birth control are okay.

Exclusion Criterias

Any medical or surgical conditions which might significantly alter bupropion absorption (e.g., history of malabsorption, liver disease, gastric bypass surgery )
Alcohol dependence
Nicotine dependence
...
Any medical or surgical conditions which might significantly alter bupropion absorption (e.g., history of malabsorption, liver disease, gastric bypass surgery )
Alcohol dependence
Nicotine dependence
Individuals unwilling or unable to comply with the study protocol (e.g. unable to remain medication or supplement free during the study).
Individuals with a history of psychiatric or neurological illness, including seizure disorders
Pregnant or nursing women
Individuals unwilling or unable to take bupropion or have an allergy to bupropion

Locations

Ann Arbor, Michigan, 48109-2700
Ann Arbor, Michigan, 48109-2700

Tracking Information

NCT #
NCT02078180
Collaborators
Not Provided
Investigators
  • Principal Investigator: Duxin Sun, PhD University of Michigan
  • Duxin Sun, PhD University of Michigan