Recruitment

Recruitment Status
Completed
Estimated Enrollment
50

Inclusion Criteria

Ability to give written informed consent.
Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
DSM diagnosis of schizophrenia or schizoaffective disorder.
...
Ability to give written informed consent.
Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
DSM diagnosis of schizophrenia or schizoaffective disorder.
Four weeks of stable pharmacological treatment (same psychiatric medication at same dose) and no foreseeable changes at enrollment.
Normal or corrected to normal vision (at least 20/50).
Aged 18-60 years.

Exclusion Criteria

Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
Mental retardation.
...
Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
Mental retardation.
Alcohol or substance abuse or dependence other than nicotine within the last 12 months.
ECG abnormalities.
History of neurological conditions such as stroke, seizures, dementia or organic brain syndrome.
Treated with benztropine currently or within the last four weeks.
Breast-feeding.
Pregnant, verified by urine pregnancy test for females.

Summary

Conditions
  • Schizoaffective Disorder
  • Schizophrenia
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 18 years and 60 years
Gender
Both males and females

Inclusion Criteria

Ability to give written informed consent.
Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
DSM diagnosis of schizophrenia or schizoaffective disorder.
...
Ability to give written informed consent.
Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
DSM diagnosis of schizophrenia or schizoaffective disorder.
Four weeks of stable pharmacological treatment (same psychiatric medication at same dose) and no foreseeable changes at enrollment.
Normal or corrected to normal vision (at least 20/50).
Aged 18-60 years.

Exclusion Criteria

Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
Mental retardation.
...
Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
Mental retardation.
Alcohol or substance abuse or dependence other than nicotine within the last 12 months.
ECG abnormalities.
History of neurological conditions such as stroke, seizures, dementia or organic brain syndrome.
Treated with benztropine currently or within the last four weeks.
Breast-feeding.
Pregnant, verified by urine pregnancy test for females.

Tracking Information

NCT #
NCT02069392
Collaborators
National Institute of Mental Health (NIMH)
Investigators
  • Principal Investigator: Britta Hahn, Ph.D. University of Maryland School of Medicine, Maryland Psychiatric Research Center
  • Britta Hahn, Ph.D. University of Maryland School of Medicine, Maryland Psychiatric Research Center
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