Nicotinic Enhancement of Cognitive Remediation Training in Schizophrenia
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
- Estimated Enrollment
- 50
Inclusion Criteria
- Aged 18-60 years.
- DSM diagnosis of schizophrenia or schizoaffective disorder.
- Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
- ...
- Aged 18-60 years.
- DSM diagnosis of schizophrenia or schizoaffective disorder.
- Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
- Four weeks of stable pharmacological treatment (same psychiatric medication at same dose) and no foreseeable changes at enrollment.
- Ability to give written informed consent.
- Normal or corrected to normal vision (at least 20/50).
Exclusion Criteria
- ECG abnormalities.
- Mental retardation.
- Alcohol or substance abuse or dependence other than nicotine within the last 12 months.
- ...
- ECG abnormalities.
- Mental retardation.
- Alcohol or substance abuse or dependence other than nicotine within the last 12 months.
- History of neurological conditions such as stroke, seizures, dementia or organic brain syndrome.
- Breast-feeding.
- Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
- Treated with benztropine currently or within the last four weeks.
- History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
- Pregnant, verified by urine pregnancy test for females.
Summary
- Conditions
- Schizoaffective Disorder
- Schizophrenia
- Type
- Interventional
- Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 60 years
- Gender
- Both males and females
Inclusion Criteria
- Aged 18-60 years.
- DSM diagnosis of schizophrenia or schizoaffective disorder.
- Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
- ...
- Aged 18-60 years.
- DSM diagnosis of schizophrenia or schizoaffective disorder.
- Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
- Four weeks of stable pharmacological treatment (same psychiatric medication at same dose) and no foreseeable changes at enrollment.
- Ability to give written informed consent.
- Normal or corrected to normal vision (at least 20/50).
Exclusion Criteria
- ECG abnormalities.
- Mental retardation.
- Alcohol or substance abuse or dependence other than nicotine within the last 12 months.
- ...
- ECG abnormalities.
- Mental retardation.
- Alcohol or substance abuse or dependence other than nicotine within the last 12 months.
- History of neurological conditions such as stroke, seizures, dementia or organic brain syndrome.
- Breast-feeding.
- Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
- Treated with benztropine currently or within the last four weeks.
- History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
- Pregnant, verified by urine pregnancy test for females.
Tracking Information
- NCT #
- NCT02069392
- Collaborators
- National Institute of Mental Health (NIMH)
- Investigators
- Principal Investigator: Britta Hahn, Ph.D. University of Maryland School of Medicine, Maryland Psychiatric Research Center
- Britta Hahn, Ph.D. University of Maryland School of Medicine, Maryland Psychiatric Research Center
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