Recruitment

Recruitment Status
Completed
Estimated Enrollment
50

Inclusion Criteria

Aged 18-60 years.
Normal or corrected to normal vision (at least 20/50).
Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
...
Aged 18-60 years.
Normal or corrected to normal vision (at least 20/50).
Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
Ability to give written informed consent.
Four weeks of stable pharmacological treatment (same psychiatric medication at same dose) and no foreseeable changes at enrollment.
DSM diagnosis of schizophrenia or schizoaffective disorder.

Exclusion Criteria

Treated with benztropine currently or within the last four weeks.
History of neurological conditions such as stroke, seizures, dementia or organic brain syndrome.
Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
...
Treated with benztropine currently or within the last four weeks.
History of neurological conditions such as stroke, seizures, dementia or organic brain syndrome.
Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
ECG abnormalities.
Pregnant, verified by urine pregnancy test for females.
Mental retardation.
Alcohol or substance abuse or dependence other than nicotine within the last 12 months.
History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
Breast-feeding.

Summary

Conditions
  • Schizoaffective Disorder
  • Schizophrenia
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 18 years and 60 years
Gender
Both males and females

Inclusion Criteria

Aged 18-60 years.
Normal or corrected to normal vision (at least 20/50).
Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
...
Aged 18-60 years.
Normal or corrected to normal vision (at least 20/50).
Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
Ability to give written informed consent.
Four weeks of stable pharmacological treatment (same psychiatric medication at same dose) and no foreseeable changes at enrollment.
DSM diagnosis of schizophrenia or schizoaffective disorder.

Exclusion Criteria

Treated with benztropine currently or within the last four weeks.
History of neurological conditions such as stroke, seizures, dementia or organic brain syndrome.
Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
...
Treated with benztropine currently or within the last four weeks.
History of neurological conditions such as stroke, seizures, dementia or organic brain syndrome.
Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
ECG abnormalities.
Pregnant, verified by urine pregnancy test for females.
Mental retardation.
Alcohol or substance abuse or dependence other than nicotine within the last 12 months.
History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
Breast-feeding.

Tracking Information

NCT #
NCT02069392
Collaborators
National Institute of Mental Health (NIMH)
Investigators
  • Principal Investigator: Britta Hahn, Ph.D. University of Maryland School of Medicine, Maryland Psychiatric Research Center
  • Britta Hahn, Ph.D. University of Maryland School of Medicine, Maryland Psychiatric Research Center
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