Nicotinic Enhancement of Cognitive Remediation Training in Schizophrenia
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
- Estimated Enrollment
- 50
Inclusion Criteria
- Aged 18-60 years.
- DSM diagnosis of schizophrenia or schizoaffective disorder.
- Four weeks of stable pharmacological treatment (same psychiatric medication at same dose) and no foreseeable changes at enrollment.
- ...
- Aged 18-60 years.
- DSM diagnosis of schizophrenia or schizoaffective disorder.
- Four weeks of stable pharmacological treatment (same psychiatric medication at same dose) and no foreseeable changes at enrollment.
- Ability to give written informed consent.
- Normal or corrected to normal vision (at least 20/50).
- Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
Exclusion Criteria
- History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
- Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
- Pregnant, verified by urine pregnancy test for females.
- ...
- History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
- Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
- Pregnant, verified by urine pregnancy test for females.
- History of neurological conditions such as stroke, seizures, dementia or organic brain syndrome.
- Breast-feeding.
- Treated with benztropine currently or within the last four weeks.
- Alcohol or substance abuse or dependence other than nicotine within the last 12 months.
- Mental retardation.
- ECG abnormalities.
Summary
- Conditions
- Schizoaffective Disorder
- Schizophrenia
- Type
- Interventional
- Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
Participation Requirements
- Age
- Between 18 years and 60 years
- Gender
- Both males and females
Inclusion Criteria
- Aged 18-60 years.
- DSM diagnosis of schizophrenia or schizoaffective disorder.
- Four weeks of stable pharmacological treatment (same psychiatric medication at same dose) and no foreseeable changes at enrollment.
- ...
- Aged 18-60 years.
- DSM diagnosis of schizophrenia or schizoaffective disorder.
- Four weeks of stable pharmacological treatment (same psychiatric medication at same dose) and no foreseeable changes at enrollment.
- Ability to give written informed consent.
- Normal or corrected to normal vision (at least 20/50).
- Either currently smoking and not attempting to quit, or having smoked no more than 80 cigarettes, cigarillos or cigars in lifetime and not at all within the last year.
Exclusion Criteria
- History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
- Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
- Pregnant, verified by urine pregnancy test for females.
- ...
- History of myocardial infarction, heart failure, angina, stroke or severe arrhythmias.
- Uncontrolled hypertension (resting systolic blood pressure above 150 or diastolic above 90 mm Hg).
- Pregnant, verified by urine pregnancy test for females.
- History of neurological conditions such as stroke, seizures, dementia or organic brain syndrome.
- Breast-feeding.
- Treated with benztropine currently or within the last four weeks.
- Alcohol or substance abuse or dependence other than nicotine within the last 12 months.
- Mental retardation.
- ECG abnormalities.
Tracking Information
- NCT #
- NCT02069392
- Collaborators
- National Institute of Mental Health (NIMH)
- Investigators
- Principal Investigator: Britta Hahn, Ph.D. University of Maryland School of Medicine, Maryland Psychiatric Research Center
- Britta Hahn, Ph.D. University of Maryland School of Medicine, Maryland Psychiatric Research Center
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