Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
Inclusion Criteria
- Aged 18-50
- Healthy volunteers
- 50-100 kg
- Aged 18-50
- Healthy volunteers
- 50-100 kg
Exclusion Criteria
- Primary relatives with current or previous migraine
- Hypotension
- Respiratory or cardiac disease
- ...
- Primary relatives with current or previous migraine
- Hypotension
- Respiratory or cardiac disease
- Pregnant or lactating women
- Other primary headaches
- Exposure to radiation within the last year
- Drug taken within 4 times the halflife for the specific drug except contraceptives
- Hypertension
- Tension type headache more than once/month
- Headache within the last 24 hours before start of trial
- Daily medication except contraceptives
- Smoking
Summary
- Conditions
- Headache
- Migraine
- Type
- Interventional
- Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
Participation Requirements
- Age
- Between 18 years and 50 years
- Gender
- Both males and females
Description
To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide. With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial tempo...
To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide. With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.
Inclusion Criteria
- Aged 18-50
- Healthy volunteers
- 50-100 kg
- Aged 18-50
- Healthy volunteers
- 50-100 kg
Exclusion Criteria
- Primary relatives with current or previous migraine
- Hypotension
- Respiratory or cardiac disease
- ...
- Primary relatives with current or previous migraine
- Hypotension
- Respiratory or cardiac disease
- Pregnant or lactating women
- Other primary headaches
- Exposure to radiation within the last year
- Drug taken within 4 times the halflife for the specific drug except contraceptives
- Hypertension
- Tension type headache more than once/month
- Headache within the last 24 hours before start of trial
- Daily medication except contraceptives
- Smoking
Tracking Information
- NCT #
- NCT02066558
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Nanna Arngrim, MD Danish Headache Center, Glostrup Hospital
- Nanna Arngrim, MD Danish Headache Center, Glostrup Hospital
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