Recruitment

Recruitment Status
Completed

Inclusion Criteria

50-100 kg
Aged 18-50
Healthy volunteers
50-100 kg
Aged 18-50
Healthy volunteers

Exclusion Criteria

Drug taken within 4 times the halflife for the specific drug except contraceptives
Hypotension
Headache within the last 24 hours before start of trial
...
Drug taken within 4 times the halflife for the specific drug except contraceptives
Hypotension
Headache within the last 24 hours before start of trial
Exposure to radiation within the last year
Other primary headaches
Primary relatives with current or previous migraine
Smoking
Respiratory or cardiac disease
Daily medication except contraceptives
Hypertension
Pregnant or lactating women
Tension type headache more than once/month

Summary

Conditions
  • Headache
  • Migraine
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Crossover Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Basic Science

Participation Requirements

Age
Between 18 years and 50 years
Gender
Both males and females

Description

To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide. With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial tempo...

To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide. With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.

Inclusion Criteria

50-100 kg
Aged 18-50
Healthy volunteers
50-100 kg
Aged 18-50
Healthy volunteers

Exclusion Criteria

Drug taken within 4 times the halflife for the specific drug except contraceptives
Hypotension
Headache within the last 24 hours before start of trial
...
Drug taken within 4 times the halflife for the specific drug except contraceptives
Hypotension
Headache within the last 24 hours before start of trial
Exposure to radiation within the last year
Other primary headaches
Primary relatives with current or previous migraine
Smoking
Respiratory or cardiac disease
Daily medication except contraceptives
Hypertension
Pregnant or lactating women
Tension type headache more than once/month

Tracking Information

NCT #
NCT02066558
Collaborators
Not Provided
Investigators
  • Principal Investigator: Nanna Arngrim, MD Danish Headache Center, Glostrup Hospital
  • Nanna Arngrim, MD Danish Headache Center, Glostrup Hospital