Study of Adaptation of the Right Ventricle to Systemic Afterload
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
Exclusion Criteria
- History of myocardial infarction-known or detectable on the ECG-abnormal Liver function tests
- Complete Blood Count
- electrolytes
- ...
- History of myocardial infarction-known or detectable on the ECG-abnormal Liver function tests
- Complete Blood Count
- electrolytes
- viral serology
- Patient with severe renal clearance less than Glomerular Filtration Rate inf 30ml/mn/1.73m²
- History of thoracic radiotherapy or chemotherapy
- Contraindications MRI
- Patient has already made a severe allergy to gadolinium MRI contrast Current Pregnancy
- Counter-indication for performing a stress test
- Primary or secondary cardiomyopathy-known or detectable on echocardiography
Summary
- Conditions
- Congenital Heart Disease With Systemic Right Ventricle
- Type
- Interventional
- Design
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
Right ventricle (RV) in sub-aortic position is a rare situation, mainly in two congenital heart defects: congenitally corrected transposition of the great arteries and complete transposition of the great arteries palliated by atrial switch. In these patients, increase of afterload leads to hypertrop...
Right ventricle (RV) in sub-aortic position is a rare situation, mainly in two congenital heart defects: congenitally corrected transposition of the great arteries and complete transposition of the great arteries palliated by atrial switch. In these patients, increase of afterload leads to hypertrophy and late RV dilatation. The stress exercised on RV walls could play a role in adaptative mechanisms to systemic afterload. Beyond a remodelling threshold, it could cause fibrosis damage and RV systolic failure. Magnetic resonance imaging, which has a major potential in estimation of RV remodelling, wall stress and fibrosis, could shed light on RV adaptation to systemic afterload and evolution towards failure. Systemic RV remodelling and function could also depend on the neuro-hormone secretion and mechanical arterial properties, that have a direct influence on patients afterload. The first purpose of the study is to determine the adaptative mechanisms of RV to systemic afterload, and the mechanisms of RV failure, in patients with congenital heart disease and subaortic RV, using cardiac magnetic resonance imaging (CMR).The mechanisms are evaluated by measures of RV remodelling and RV wall stress using CMR. Second objectives are to evaluate these mechanisms using echography, arterial properties study and neurohormonal levels
Exclusion Criteria
- History of myocardial infarction-known or detectable on the ECG-abnormal Liver function tests
- Complete Blood Count
- electrolytes
- ...
- History of myocardial infarction-known or detectable on the ECG-abnormal Liver function tests
- Complete Blood Count
- electrolytes
- viral serology
- Patient with severe renal clearance less than Glomerular Filtration Rate inf 30ml/mn/1.73m²
- History of thoracic radiotherapy or chemotherapy
- Contraindications MRI
- Patient has already made a severe allergy to gadolinium MRI contrast Current Pregnancy
- Counter-indication for performing a stress test
- Primary or secondary cardiomyopathy-known or detectable on echocardiography
Tracking Information
- NCT #
- NCT02066506
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Magalie Ladouceur, MD Université Paris Descartes
- Magalie Ladouceur, MD Université Paris Descartes
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