REWARD SYSTEM RESPONSES TO FOOD AROMAS
Last updated on April 2022Recruitment
- Recruitment Status
- Unknown status
Inclusion Criteria
- good health without self reported neurological or psychiatric disorder
- no indication of eating disorders
- normal sense of smell
- ...
- good health without self reported neurological or psychiatric disorder
- no indication of eating disorders
- normal sense of smell
- non smoking, right handed women 18-40 years
Exclusion Criteria
- history of drug abuse/dependence, positive drug screen for amphetamines/methamphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates or PCP
- contraindications to MRI (ferrous material, claustrophobia)
- DSM-IV axis I psychiatric disorders or head injury with loss of consciousness
- ...
- history of drug abuse/dependence, positive drug screen for amphetamines/methamphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates or PCP
- contraindications to MRI (ferrous material, claustrophobia)
- DSM-IV axis I psychiatric disorders or head injury with loss of consciousness
- pregnant,/breast feeding women
Summary
- Conditions
- Adiposity
- Type
- Observational
- Design
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
Participation Requirements
- Age
- Between 18 years and 40 years
- Gender
- Only females
Description
Food aromas are powerful appetitive cues that are intrinsic to foods' flavor and hedonic qualities, and such cues can facilitate overeating. Alcohol consumption similarly "primes" appetite, and contributes to overeating while under alcohol's acute effects. Knowing the brain loci that respond to such...
Food aromas are powerful appetitive cues that are intrinsic to foods' flavor and hedonic qualities, and such cues can facilitate overeating. Alcohol consumption similarly "primes" appetite, and contributes to overeating while under alcohol's acute effects. Knowing the brain loci that respond to such naturalistic appetitive stimuli, and how they are modified by body fat and alcohol exposure, will provide critical insights about the neural systems that underlie loss of control of eating. Therefore, the main hypotheses of this study are that: A) Lean and obese subjects have different limbic responses to the olfactory cues that enhance motivation to eat, and B) Acute alcohol intoxication i) potentiates the brain's reward system response to food odors, and ii) affects brain systems involved in behavioral inhibition and eating restraint. To test these hypotheses, we have modified functional magnetic resonance imaging (fMRI) paradigms successfully used to study alcoholic drink aromas in subjects at risk for alcoholism.
Inclusion Criteria
- good health without self reported neurological or psychiatric disorder
- no indication of eating disorders
- normal sense of smell
- ...
- good health without self reported neurological or psychiatric disorder
- no indication of eating disorders
- normal sense of smell
- non smoking, right handed women 18-40 years
Exclusion Criteria
- history of drug abuse/dependence, positive drug screen for amphetamines/methamphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates or PCP
- contraindications to MRI (ferrous material, claustrophobia)
- DSM-IV axis I psychiatric disorders or head injury with loss of consciousness
- ...
- history of drug abuse/dependence, positive drug screen for amphetamines/methamphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates or PCP
- contraindications to MRI (ferrous material, claustrophobia)
- DSM-IV axis I psychiatric disorders or head injury with loss of consciousness
- pregnant,/breast feeding women
Tracking Information
- NCT #
- NCT02041039
- Collaborators
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Investigators
- Not Provided
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