Recruitment

Recruitment Status
Unknown status

Inclusion Criteria

normal sense of smell
non smoking, right handed women 18-40 years
good health without self reported neurological or psychiatric disorder
...
normal sense of smell
non smoking, right handed women 18-40 years
good health without self reported neurological or psychiatric disorder
no indication of eating disorders

Exclusion Criteria

contraindications to MRI (ferrous material, claustrophobia)
DSM-IV axis I psychiatric disorders or head injury with loss of consciousness
pregnant,/breast feeding women
...
contraindications to MRI (ferrous material, claustrophobia)
DSM-IV axis I psychiatric disorders or head injury with loss of consciousness
pregnant,/breast feeding women
history of drug abuse/dependence, positive drug screen for amphetamines/methamphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates or PCP

Summary

Conditions
Adiposity
Type
Observational
Design
  • Observational Model: Case-Control
  • Time Perspective: Cross-Sectional

Participation Requirements

Age
Between 18 years and 40 years
Gender
Only females

Description

Food aromas are powerful appetitive cues that are intrinsic to foods' flavor and hedonic qualities, and such cues can facilitate overeating. Alcohol consumption similarly "primes" appetite, and contributes to overeating while under alcohol's acute effects. Knowing the brain loci that respond to such...

Food aromas are powerful appetitive cues that are intrinsic to foods' flavor and hedonic qualities, and such cues can facilitate overeating. Alcohol consumption similarly "primes" appetite, and contributes to overeating while under alcohol's acute effects. Knowing the brain loci that respond to such naturalistic appetitive stimuli, and how they are modified by body fat and alcohol exposure, will provide critical insights about the neural systems that underlie loss of control of eating. Therefore, the main hypotheses of this study are that: A) Lean and obese subjects have different limbic responses to the olfactory cues that enhance motivation to eat, and B) Acute alcohol intoxication i) potentiates the brain's reward system response to food odors, and ii) affects brain systems involved in behavioral inhibition and eating restraint. To test these hypotheses, we have modified functional magnetic resonance imaging (fMRI) paradigms successfully used to study alcoholic drink aromas in subjects at risk for alcoholism.

Inclusion Criteria

normal sense of smell
non smoking, right handed women 18-40 years
good health without self reported neurological or psychiatric disorder
...
normal sense of smell
non smoking, right handed women 18-40 years
good health without self reported neurological or psychiatric disorder
no indication of eating disorders

Exclusion Criteria

contraindications to MRI (ferrous material, claustrophobia)
DSM-IV axis I psychiatric disorders or head injury with loss of consciousness
pregnant,/breast feeding women
...
contraindications to MRI (ferrous material, claustrophobia)
DSM-IV axis I psychiatric disorders or head injury with loss of consciousness
pregnant,/breast feeding women
history of drug abuse/dependence, positive drug screen for amphetamines/methamphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates or PCP

Tracking Information

NCT #
NCT02041039
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
Not Provided
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