Recruitment

Recruitment Status
Unknown status

Inclusion Criterias

Diagnosis of Multiple sclerosis
Diagnosis of Multiple sclerosis

Exclusion Criterias

Diagnosis of other neurological conditions
Diagnosis of other neurological conditions

Summary

Conditions
Multiple Sclerosis
Type
Interventional
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Double (Participant, Outcomes Assessor)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 18 years and 65 years
Gender
Both males and females

Description

If self- generation can be successfully adapted and applied to a treatment program for individuals with MS, it has the potential to improve their rehabilitation and treatment by facilitating new learning and memory. In addition, if treatment and rehabilitation are successful and productive, it is ex...

If self- generation can be successfully adapted and applied to a treatment program for individuals with MS, it has the potential to improve their rehabilitation and treatment by facilitating new learning and memory. In addition, if treatment and rehabilitation are successful and productive, it is expected that the application of self-generation strategy to improve learning/ relearning will help to improve the ability of individuals with MS to maintain their current lifestyles at home, work, and within the community. We expect that persons with MS who complete the proposed treatment will acquire the trained strategy, recognize the everyday situations in which the trained strategy could be applied and then map and adapt the trained strategy to real-world situations. Fourty participants with clinically definite MS and objectively documented impairment in verbal new learning will be included in the study. Participants will be randomly assigned to either the treatment group (n=20) or the control group (n=20). Participants will be enrolled only following an informed consent procedure, with the expectation of being able to participate for the full duration of the study (6 treatment sessions and two assessment sessions). All participants enrolled in the study will undergo pre and post treatment assessment to assess their levels of cognitive, emotional, and functional performance. Treatment for both experimental and control groups will consist of 6 individualized treatment sessions, 2 x per week for 3 weeks. Each session will last for approximately 45 minutes, and will include various memory tasks that will range from learning list of words to learning tasks related to everyday life. Participants in the control group will only be asked to perform the same memory tasks as the treatment group. The treatment for the experimental group will couple self-generated learning with awareness-training techniques, which are geared toward helping patients self-discover their performance strengths and limitations through integration of direct and personal experiences. Personal experience will be gained by practicing various memory tasks using self-generation strategy. This proposed self-generation program is expected to increase memory, task specific awareness and functional performance; ultimately improving quality of life and self-regulation.

Inclusion Criterias

Diagnosis of Multiple sclerosis
Diagnosis of Multiple sclerosis

Exclusion Criterias

Diagnosis of other neurological conditions
Diagnosis of other neurological conditions

Locations

West Orange, New Jersey, 07052
West Orange, New Jersey, 07052

Tracking Information

NCT #
NCT02032589
Collaborators
National Multiple Sclerosis Society
Investigators
  • Principal Investigator: Yael Goverover, PhD Kessler Foundation Principal Investigator: John DeLuca, PhD Kessler Foundation
  • Yael Goverover, PhD Kessler Foundation Principal Investigator: John DeLuca, PhD Kessler Foundation