Recruitment

Recruitment Status
Recruiting
Estimated Enrollment
9999

Inclusion Criteria

Adult individuals (male and female) who have a personal diagnosis/history of cancer
19 years of age or older.
Adult individuals who have a risk for developing cancer or suspicious clinical findings
...
Adult individuals (male and female) who have a personal diagnosis/history of cancer
19 years of age or older.
Adult individuals who have a risk for developing cancer or suspicious clinical findings
Adult individuals who are able to speak English.
Adult individuals with no history of cancer for normal control registry.
Able to provide consent.

Exclusion Criteria

Individuals under age 19.
Anyone who does not meet the above inclusion criteria for this project.
Non-English speaking individuals.
...
Individuals under age 19.
Anyone who does not meet the above inclusion criteria for this project.
Non-English speaking individuals.
Individuals unable to provide informed consent by virtue of cognitive impairment.

Summary

Conditions
  • Bladder Cancer
  • Colon Cancer
  • Anal Cancer
  • Gallbladder Cancer
  • GIST
  • Plasma Cell Dyscrasia
  • Salivary Gland Cancer
  • Bile Duct Cancer
  • Lynch Syndrome
  • Leukemia
  • Sarcoma
  • Mesothelioma
  • Hypopharyngeal Cancer
  • Laryngeal Cancer
  • Thymus Cancer
  • Vaginal Cancer
  • Rectal Cancer
  • Urethral Cancer
  • Multiple Myeloma
  • Neuroendocrine Tumors
  • Skin Cancer
  • Small Intestine Cancer
  • Breast Cancer
  • Liver Cancer
  • Nasopharyngeal Cancer
  • Nasal Cavity Cancer
  • CNS Cancer
  • CNS Tumor
  • Oral Cavity Cancer
  • Prostate Cancer
  • Duodenal Cancer
  • Paranasal Sinus Cancer
  • Lip Cancer
  • Ureter Cancer
  • Melanoma
  • Oropharyngeal Cancer
  • Lung Cancer
  • Endometrial Cancer
  • Pancreatic Cancer
  • Gastric Cancer
  • Healthy Control
  • Peritoneal Surface Malignancies
  • Testicular Cancer
  • Thyroid Cancer
  • Unknown Primary Tumor
  • Kidney Cancer
  • Esophageal Cancer
  • Familial Adenomatous Polyposis
  • Ovarian Cancer
  • Penile Cancer
Design
  • Observational Model: Cohort
  • Time Perspective: Prospective

Participation Requirements

Age
Between 19 years and 110 years
Gender
Both males and females

Description

The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a m...

The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a multi-center, semantically-interoperable and easily-customizable cancer data resource which is aimed at collecting, managing, mining and sharing the comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens (such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those individuals. The iCaRe2 provides: (i) a HIPAA compliant, secure, efficient and user-friendly mechanism for data and validation; (ii) utilization of standard vocabulary and data elements; and (iii) the ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care. The iCaRe2 has been developed as an expansion of the biocomputing framework that initially included four multi-center collaborative registries: (i) the PCCR (Pancreatic Cancer Collaborative Registry that was established in 2001), (ii) the BCCR (Breast Cancer Collaborative Registry - established in 2006 ); (iii) the TCCR (Thyroid Cancer Collaborative Registry - established in 2006), and (iv) the GPHID (Great Plains Health Informatics Database - established in 2011 to enroll subjects who have no personal history of cancer diagnosis at the time of enrollment). At present, this framework has been incrementally expanded to include the Thoracic Oncology Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCARE), Head and Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal & Abdominal Cavity Cancer Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR), Leukemia and Myeloid Neoplasm Registry (LEMN) , Gynecological Cancer Collaborative Registry (GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR), Plasma Cell Dyscrasias Collaborative Registry (PDCR), Neuroendocrine Collaborative Registry (NETR), and Auxiliary Cancer Registry (ACR). The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry or network model. It was felt that these latter models implied that the registry or network would assume control of an individual Center's database. The major advantages of a confederation model include the flexibility to use selected Centers for different research projects based on a Center's resources and expertise and the ability to have different strategies to address various research questions. It was also recognized that for this model to be successful, it is essential to have a standardized approach to data collection (patient information and biospecimen annotation) and reporting. A confederation would also encourage participation of any interested Center, irrespective of its size or location. A web-based registry iCaRe2 was developed and made available to any Center to participate in data collection and storage of cancer related data.

Inclusion Criteria

Adult individuals (male and female) who have a personal diagnosis/history of cancer
19 years of age or older.
Adult individuals who have a risk for developing cancer or suspicious clinical findings
...
Adult individuals (male and female) who have a personal diagnosis/history of cancer
19 years of age or older.
Adult individuals who have a risk for developing cancer or suspicious clinical findings
Adult individuals who are able to speak English.
Adult individuals with no history of cancer for normal control registry.
Able to provide consent.

Exclusion Criteria

Individuals under age 19.
Anyone who does not meet the above inclusion criteria for this project.
Non-English speaking individuals.
...
Individuals under age 19.
Anyone who does not meet the above inclusion criteria for this project.
Non-English speaking individuals.
Individuals unable to provide informed consent by virtue of cognitive impairment.

Tracking Information

NCT #
NCT02012699
Collaborators
Not Provided
Investigators
  • Principal Investigator: Whitney Goldner, MD University of Nebraska
  • Whitney Goldner, MD University of Nebraska