Recruitment

Recruitment Status
Recruiting
Estimated Enrollment
9999

Inclusion Criteria

Adult individuals with no history of cancer for normal control registry.
19 years of age or older.
Adult individuals who are able to speak English.
...
Adult individuals with no history of cancer for normal control registry.
19 years of age or older.
Adult individuals who are able to speak English.
Able to provide consent.
Adult individuals who have a risk for developing cancer or suspicious clinical findings
Adult individuals (male and female) who have a personal diagnosis/history of cancer

Exclusion Criteria

Individuals unable to provide informed consent by virtue of cognitive impairment.
Anyone who does not meet the above inclusion criteria for this project.
Non-English speaking individuals.
...
Individuals unable to provide informed consent by virtue of cognitive impairment.
Anyone who does not meet the above inclusion criteria for this project.
Non-English speaking individuals.
Individuals under age 19.

Summary

Conditions
  • Breast Cancer
  • Anal Cancer
  • Bile Duct Cancer
  • Healthy Control
  • Gallbladder Cancer
  • Lynch Syndrome
  • Melanoma
  • Plasma Cell Dyscrasia
  • Multiple Myeloma
  • Bladder Cancer
  • Skin Cancer
  • Pancreatic Cancer
  • Rectal Cancer
  • Nasal Cavity Cancer
  • Oral Cavity Cancer
  • Peritoneal Surface Malignancies
  • CNS Cancer
  • Thyroid Cancer
  • Thymus Cancer
  • Ureter Cancer
  • Neuroendocrine Tumors
  • Penile Cancer
  • CNS Tumor
  • Laryngeal Cancer
  • Hypopharyngeal Cancer
  • Vaginal Cancer
  • Small Intestine Cancer
  • Testicular Cancer
  • Oropharyngeal Cancer
  • Sarcoma
  • Colon Cancer
  • Duodenal Cancer
  • Endometrial Cancer
  • Leukemia
  • Unknown Primary Tumor
  • Lung Cancer
  • Prostate Cancer
  • Ovarian Cancer
  • Lip Cancer
  • Esophageal Cancer
  • Mesothelioma
  • Salivary Gland Cancer
  • Kidney Cancer
  • Gastric Cancer
  • GIST
  • Paranasal Sinus Cancer
  • Urethral Cancer
  • Liver Cancer
  • Nasopharyngeal Cancer
  • Familial Adenomatous Polyposis
Design
  • Observational Model: Cohort
  • Time Perspective: Prospective

Participation Requirements

Age
Between 19 years and 110 years
Gender
Both males and females

Description

The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a m...

The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a multi-center, semantically-interoperable and easily-customizable cancer data resource which is aimed at collecting, managing, mining and sharing the comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens (such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those individuals. The iCaRe2 provides: (i) a HIPAA compliant, secure, efficient and user-friendly mechanism for data and validation; (ii) utilization of standard vocabulary and data elements; and (iii) the ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care. The iCaRe2 has been developed as an expansion of the biocomputing framework that initially included four multi-center collaborative registries: (i) the PCCR (Pancreatic Cancer Collaborative Registry that was established in 2001), (ii) the BCCR (Breast Cancer Collaborative Registry - established in 2006 ); (iii) the TCCR (Thyroid Cancer Collaborative Registry - established in 2006), and (iv) the GPHID (Great Plains Health Informatics Database - established in 2011 to enroll subjects who have no personal history of cancer diagnosis at the time of enrollment). At present, this framework has been incrementally expanded to include the Thoracic Oncology Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCARE), Head and Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal & Abdominal Cavity Cancer Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR), Leukemia and Myeloid Neoplasm Registry (LEMN) , Gynecological Cancer Collaborative Registry (GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR), Plasma Cell Dyscrasias Collaborative Registry (PDCR), Neuroendocrine Collaborative Registry (NETR), and Auxiliary Cancer Registry (ACR). The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry or network model. It was felt that these latter models implied that the registry or network would assume control of an individual Center's database. The major advantages of a confederation model include the flexibility to use selected Centers for different research projects based on a Center's resources and expertise and the ability to have different strategies to address various research questions. It was also recognized that for this model to be successful, it is essential to have a standardized approach to data collection (patient information and biospecimen annotation) and reporting. A confederation would also encourage participation of any interested Center, irrespective of its size or location. A web-based registry iCaRe2 was developed and made available to any Center to participate in data collection and storage of cancer related data.

Inclusion Criteria

Adult individuals with no history of cancer for normal control registry.
19 years of age or older.
Adult individuals who are able to speak English.
...
Adult individuals with no history of cancer for normal control registry.
19 years of age or older.
Adult individuals who are able to speak English.
Able to provide consent.
Adult individuals who have a risk for developing cancer or suspicious clinical findings
Adult individuals (male and female) who have a personal diagnosis/history of cancer

Exclusion Criteria

Individuals unable to provide informed consent by virtue of cognitive impairment.
Anyone who does not meet the above inclusion criteria for this project.
Non-English speaking individuals.
...
Individuals unable to provide informed consent by virtue of cognitive impairment.
Anyone who does not meet the above inclusion criteria for this project.
Non-English speaking individuals.
Individuals under age 19.

Locations

Indianapolis, Indiana, 46219
North Platte, Nebraska, 69101
Portland, Maine, 04102
Westminster, Colorado, 80228
Davenport, Iowa, 52804
...
Indianapolis, Indiana, 46219
North Platte, Nebraska, 69101
Portland, Maine, 04102
Westminster, Colorado, 80228
Davenport, Iowa, 52804
Brookfield, Wisconsin, 53045
Saint Joseph, Missouri, 64507
Louisville, Colorado, 80027
Yankton, South Dakota, 57078
Ann Arbor, Michigan, 48109
Kalispell, Montana, 59901
Fargo, North Dakota, 58103
Minot, North Dakota, 58701
Yankton, South Dakota, 57078
Appleton, Wisconsin, 54915
Omaha, Nebraska, 68114
Moline, Illinois, 61265
New Orleans, Louisiana, 70112
Aitkin, Minnesota, 56431
Lakewood, Colorado, 80228
Sioux Falls, South Dakota, 57105
Waterloo, Iowa, 50702
Denver, Colorado, 80210
Westminster, Maryland, 21157
Orange City, Florida, 32763
Indianapolis, Indiana, 46227
Yankton, South Dakota, 57078
Omaha, Nebraska, 68114
Duluth, Minnesota, 55805
Yorkville, Illinois, 60560
Racine, Wisconsin, 53405
Joplin, Missouri, 64804
Franklin, Wisconsin, 53132
Hastings, Nebraska, 68901
Milwaukee, Wisconsin, 53211
Daytona Beach, Florida, 32117
Fort Wayne, Indiana, 46845
Fayetteville, North Carolina, 28304
Norfolk, Nebraska, 68701
Mitchell, South Dakota, 57301
DeLand, Florida, 32720
Kansas City, Missouri, 64086
Aurora, Illinois, 60504
Pueblo, Colorado, 81004
Spencer, Iowa, 51301
Indianapolis, Indiana, 46256
Mequon, Wisconsin, 53097
Kansas City, Missouri, 64111
Scottsbluff, Nebraska, 69361
Littleton, Colorado, 80122
Parker, Colorado, 80138
Wauwatosa, Wisconsin, 53226
Missoula, Montana, 59802
Randallstown, Maryland, 21133
Glens Falls, New York, 12801
Marshall, Minnesota, 56258
Overland Park, Kansas, 66213
Palm Coast, Florida, 32164
Duluth, Minnesota, 55805
Colorado Springs, Colorado, 80907
Pittsburgh, Pennsylvania, 15323
Durango, Colorado, 81301
Fergus Falls, Minnesota, 56537
Liberty, Missouri, 64068
Omaha, Nebraska, 68198
Oshkosh, Wisconsin, 54904
Brainerd, Minnesota, 56401
Utica, New York, 13501
Aberdeen, South Dakota, 57401
Holyoke, Massachusetts, 01040
Council Bluffs, Iowa, 51503
O'Neill, Nebraska, 68763
Sioux Falls, South Dakota, 57105
Fredericksburg, Virginia, 22401
Kokomo, Indiana, 46902
Longmont, Colorado, 80501
Kansas City, Missouri, 64118
Rutland, Vermont, 05701

Tracking Information

NCT #
NCT02012699
Collaborators
Not Provided
Investigators
  • Principal Investigator: Whitney Goldner, MD University of Nebraska
  • Whitney Goldner, MD University of Nebraska