Recruitment

Recruitment Status
Recruiting
Estimated Enrollment
9999

Inclusion Criteria

Adult individuals (male and female) who have a personal diagnosis/history of cancer
Able to provide consent.
Adult individuals who are able to speak English.
...
Adult individuals (male and female) who have a personal diagnosis/history of cancer
Able to provide consent.
Adult individuals who are able to speak English.
19 years of age or older.
Adult individuals with no history of cancer for normal control registry.
Adult individuals who have a risk for developing cancer or suspicious clinical findings

Exclusion Criteria

Non-English speaking individuals.
Individuals under age 19.
Anyone who does not meet the above inclusion criteria for this project.
...
Non-English speaking individuals.
Individuals under age 19.
Anyone who does not meet the above inclusion criteria for this project.
Individuals unable to provide informed consent by virtue of cognitive impairment.

Summary

Conditions
  • Familial Adenomatous Polyposis
  • Bile Duct Cancer
  • Anal Cancer
  • Bladder Cancer
  • Unknown Primary Tumor
  • Oral Cavity Cancer
  • Ovarian Cancer
  • Penile Cancer
  • Gastric Cancer
  • Thymus Cancer
  • Lung Cancer
  • Nasal Cavity Cancer
  • GIST
  • Breast Cancer
  • Mesothelioma
  • Neuroendocrine Tumors
  • Prostate Cancer
  • Salivary Gland Cancer
  • Paranasal Sinus Cancer
  • Kidney Cancer
  • CNS Cancer
  • CNS Tumor
  • Liver Cancer
  • Sarcoma
  • Leukemia
  • Rectal Cancer
  • Hypopharyngeal Cancer
  • Laryngeal Cancer
  • Small Intestine Cancer
  • Colon Cancer
  • Ureter Cancer
  • Duodenal Cancer
  • Endometrial Cancer
  • Melanoma
  • Gallbladder Cancer
  • Lip Cancer
  • Peritoneal Surface Malignancies
  • Skin Cancer
  • Esophageal Cancer
  • Vaginal Cancer
  • Multiple Myeloma
  • Thyroid Cancer
  • Pancreatic Cancer
  • Healthy Control
  • Urethral Cancer
  • Testicular Cancer
  • Nasopharyngeal Cancer
  • Oropharyngeal Cancer
  • Plasma Cell Dyscrasia
  • Lynch Syndrome
Design
  • Observational Model: Cohort
  • Time Perspective: Prospective

Participation Requirements

Age
Between 19 years and 110 years
Gender
Both males and females

Description

The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a m...

The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred & Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a multi-center, semantically-interoperable and easily-customizable cancer data resource which is aimed at collecting, managing, mining and sharing the comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens (such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those individuals. The iCaRe2 provides: (i) a HIPAA compliant, secure, efficient and user-friendly mechanism for data and validation; (ii) utilization of standard vocabulary and data elements; and (iii) the ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care. The iCaRe2 has been developed as an expansion of the biocomputing framework that initially included four multi-center collaborative registries: (i) the PCCR (Pancreatic Cancer Collaborative Registry that was established in 2001), (ii) the BCCR (Breast Cancer Collaborative Registry - established in 2006 ); (iii) the TCCR (Thyroid Cancer Collaborative Registry - established in 2006), and (iv) the GPHID (Great Plains Health Informatics Database - established in 2011 to enroll subjects who have no personal history of cancer diagnosis at the time of enrollment). At present, this framework has been incrementally expanded to include the Thoracic Oncology Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCARE), Head and Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal & Abdominal Cavity Cancer Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR), Leukemia and Myeloid Neoplasm Registry (LEMN) , Gynecological Cancer Collaborative Registry (GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR), Plasma Cell Dyscrasias Collaborative Registry (PDCR), Neuroendocrine Collaborative Registry (NETR), and Auxiliary Cancer Registry (ACR). The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry or network model. It was felt that these latter models implied that the registry or network would assume control of an individual Center's database. The major advantages of a confederation model include the flexibility to use selected Centers for different research projects based on a Center's resources and expertise and the ability to have different strategies to address various research questions. It was also recognized that for this model to be successful, it is essential to have a standardized approach to data collection (patient information and biospecimen annotation) and reporting. A confederation would also encourage participation of any interested Center, irrespective of its size or location. A web-based registry iCaRe2 was developed and made available to any Center to participate in data collection and storage of cancer related data.

Inclusion Criteria

Adult individuals (male and female) who have a personal diagnosis/history of cancer
Able to provide consent.
Adult individuals who are able to speak English.
...
Adult individuals (male and female) who have a personal diagnosis/history of cancer
Able to provide consent.
Adult individuals who are able to speak English.
19 years of age or older.
Adult individuals with no history of cancer for normal control registry.
Adult individuals who have a risk for developing cancer or suspicious clinical findings

Exclusion Criteria

Non-English speaking individuals.
Individuals under age 19.
Anyone who does not meet the above inclusion criteria for this project.
...
Non-English speaking individuals.
Individuals under age 19.
Anyone who does not meet the above inclusion criteria for this project.
Individuals unable to provide informed consent by virtue of cognitive impairment.

Tracking Information

NCT #
NCT02012699
Collaborators
Not Provided
Investigators
  • Principal Investigator: Whitney Goldner, MD University of Nebraska
  • Whitney Goldner, MD University of Nebraska