Recruitment

Recruitment Status
Completed

Inclusion Criterias

Age > 18 years and a diagnosis of HIV+ andlor AlDS made by standard CDC criteria.
Age > 18 years and a diagnosis of HIV+ andlor AlDS made by standard CDC criteria.

Summary

Conditions
Insulin Resistance
Type
Observational
Design
  • Observational Model: Case-Control
  • Time Perspective: Prospective

Participation Requirements

Age
Between 18 years and 125 years
Gender
Both males and females

Description

This study will test the hypothesis that chromium picolinate improves insulin-stimulated glucose uptake by increasing the insulin receptor-mediated tyrosine phosphorylation of insulin receptor substrate-1, resulting in increased association with phosphatidylinositol 3-kinase. Specific Aim 1 will ass...

This study will test the hypothesis that chromium picolinate improves insulin-stimulated glucose uptake by increasing the insulin receptor-mediated tyrosine phosphorylation of insulin receptor substrate-1, resulting in increased association with phosphatidylinositol 3-kinase. Specific Aim 1 will assess quantitative improvements in insulin-mediated glucose disposal in a placebo-controlled clinical trial of chromium supplementation with 1000mpg (19.2 pmol) of chromium as chromium picolinate, overa two-month course of therapy. The investigators have shown that the insulin resistance (i.e. the inability of insulin to stimulate glucose uptake into peripheral tissues like muscle) in patients with HIV disease is associated with a defect in the insulin-signaling pathway leading from the insulin receptor, through phosphatidylinositol 3-kinase(PI 3-K, Figure 5). A similar defect in intracellular signaling has also been reported in patients with type 2 diabetes mellitus ):15-171. The cellular mechanism of improved insulin sensitivity with chromium supplementation will be determined in Specific Aim 2. Specific Aim 2 will assess the effect of chromium supplementation on the insulin-stimulated activity of insulin receptor substrate-I-associated phosphatidylinositol 3-kinase in biopsies of muscle and fat tissue. This aim will also test the hypothesis that these physiological effects of chromium are mediated by alterations in the activity of insulin signaling. Understanding this mechanism may facilitate the design of even more effective strategies for improving insulin sensitivity.

Inclusion Criterias

Age > 18 years and a diagnosis of HIV+ andlor AlDS made by standard CDC criteria.
Age > 18 years and a diagnosis of HIV+ andlor AlDS made by standard CDC criteria.

Locations

Stony Brook, New York, 11794
Stony Brook, New York, 11794

Tracking Information

NCT #
NCT02006914
Collaborators
Not Provided
Investigators
  • Principal Investigator: Marie C Gelato, MD, PhD Stony Brook University School of Medicine Dept. Of Medicine/Endocrinology
  • Marie C Gelato, MD, PhD Stony Brook University School of Medicine Dept. Of Medicine/Endocrinology