Recruitment

Recruitment Status
Completed
Estimated Enrollment
352

Inclusion Criterias

The patient must demonstrate best corrected visual acuity (BCVA) of 20/30-20/200 (with glare testing, if necessary) in the study eye and better than 20/200 in the fellow eye.
The patient must have a corneal endothelial cell count by specular microscopy in the study eye of at least 2000 cells/mm2 with normal cell morphology.
A female patient of childbearing potential (premenopausal by medical history) must have a negative pregnancy test on Day 0 and be using an effective method of birth control (although no birth control method is 100% effective, the following are considered effective means of contraception: surgical sterilization, use of oral contraceptives, barrier contraception using either a condom or diaphragm with spermicidal gel, an intrauterine device, or contraceptive hormone implant or patch) from Screening for the duration of the study.
...
The patient must demonstrate best corrected visual acuity (BCVA) of 20/30-20/200 (with glare testing, if necessary) in the study eye and better than 20/200 in the fellow eye.
The patient must have a corneal endothelial cell count by specular microscopy in the study eye of at least 2000 cells/mm2 with normal cell morphology.
A female patient of childbearing potential (premenopausal by medical history) must have a negative pregnancy test on Day 0 and be using an effective method of birth control (although no birth control method is 100% effective, the following are considered effective means of contraception: surgical sterilization, use of oral contraceptives, barrier contraception using either a condom or diaphragm with spermicidal gel, an intrauterine device, or contraceptive hormone implant or patch) from Screening for the duration of the study.
The patient must be considered by the Investigator to have visual acuity potential greater than 20/30 in the study eye.
The patient must provide written informed consent by signing the Informed Consent approved by the Institutional Review Board (IRB).
The patient must be willing and able to understand and comply with the study procedures and to communicate meaningfully with study personnel.
Male or female patients at least 40 years of age scheduled for unilateral cataract surgery by phacoemulsification with posterior chamber intraocular lens implantation.

Exclusion Criterias

Patients who anticipate requiring treatment with any corticosteroids by any route, except inhalation, during the study.
Patients who have used topical ocular NSAIDs in the study eye within 15 days prior to Day 0.
Patients who have received any intravitreal corticosteroid delivery vehicle (e.g., Retisert, Ozurdex, Iluvien) in the study eye at any time.
...
Patients who anticipate requiring treatment with any corticosteroids by any route, except inhalation, during the study.
Patients who have used topical ocular NSAIDs in the study eye within 15 days prior to Day 0.
Patients who have received any intravitreal corticosteroid delivery vehicle (e.g., Retisert, Ozurdex, Iluvien) in the study eye at any time.
Patients with planned intraocular or laser surgery in the study eye for the duration of the study.
Patients with an allergy or hypersensitivity to dexamethasone.
Patients who have received a periocular corticosteroid injection in the study eye in the 3 months prior to screening.
Patients who are known steroid responders (corticosteroid-related intraocular pressure elevation in either eye).
Patients who have undergone prior intraocular laser surgery in the study eye within 3 months prior to screening.
Patients who have used any ocular, topical or oral corticosteroids within 7 days prior to Day 0.
Patients who have undergone prior intraocular (non-laser) surgery in the study eye within 6 months prior to screening.

Summary

Conditions
  • Cataracts
  • Inflammation
Type
Interventional
Phase
Phase 3
Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Primary Purpose: Treatment

Participation Requirements

Age
Between 40 years and 125 years
Gender
Both males and females

Description

A double blinded randomized trial to assess the efficacy and safety of IBI-10090, in two separate doses as compared to placebo (ATEC carrier only sans dexamethasone)

A double blinded randomized trial to assess the efficacy and safety of IBI-10090, in two separate doses as compared to placebo (ATEC carrier only sans dexamethasone)

Inclusion Criterias

The patient must demonstrate best corrected visual acuity (BCVA) of 20/30-20/200 (with glare testing, if necessary) in the study eye and better than 20/200 in the fellow eye.
The patient must have a corneal endothelial cell count by specular microscopy in the study eye of at least 2000 cells/mm2 with normal cell morphology.
A female patient of childbearing potential (premenopausal by medical history) must have a negative pregnancy test on Day 0 and be using an effective method of birth control (although no birth control method is 100% effective, the following are considered effective means of contraception: surgical sterilization, use of oral contraceptives, barrier contraception using either a condom or diaphragm with spermicidal gel, an intrauterine device, or contraceptive hormone implant or patch) from Screening for the duration of the study.
...
The patient must demonstrate best corrected visual acuity (BCVA) of 20/30-20/200 (with glare testing, if necessary) in the study eye and better than 20/200 in the fellow eye.
The patient must have a corneal endothelial cell count by specular microscopy in the study eye of at least 2000 cells/mm2 with normal cell morphology.
A female patient of childbearing potential (premenopausal by medical history) must have a negative pregnancy test on Day 0 and be using an effective method of birth control (although no birth control method is 100% effective, the following are considered effective means of contraception: surgical sterilization, use of oral contraceptives, barrier contraception using either a condom or diaphragm with spermicidal gel, an intrauterine device, or contraceptive hormone implant or patch) from Screening for the duration of the study.
The patient must be considered by the Investigator to have visual acuity potential greater than 20/30 in the study eye.
The patient must provide written informed consent by signing the Informed Consent approved by the Institutional Review Board (IRB).
The patient must be willing and able to understand and comply with the study procedures and to communicate meaningfully with study personnel.
Male or female patients at least 40 years of age scheduled for unilateral cataract surgery by phacoemulsification with posterior chamber intraocular lens implantation.

Exclusion Criterias

Patients who anticipate requiring treatment with any corticosteroids by any route, except inhalation, during the study.
Patients who have used topical ocular NSAIDs in the study eye within 15 days prior to Day 0.
Patients who have received any intravitreal corticosteroid delivery vehicle (e.g., Retisert, Ozurdex, Iluvien) in the study eye at any time.
...
Patients who anticipate requiring treatment with any corticosteroids by any route, except inhalation, during the study.
Patients who have used topical ocular NSAIDs in the study eye within 15 days prior to Day 0.
Patients who have received any intravitreal corticosteroid delivery vehicle (e.g., Retisert, Ozurdex, Iluvien) in the study eye at any time.
Patients with planned intraocular or laser surgery in the study eye for the duration of the study.
Patients with an allergy or hypersensitivity to dexamethasone.
Patients who have received a periocular corticosteroid injection in the study eye in the 3 months prior to screening.
Patients who are known steroid responders (corticosteroid-related intraocular pressure elevation in either eye).
Patients who have undergone prior intraocular laser surgery in the study eye within 3 months prior to screening.
Patients who have used any ocular, topical or oral corticosteroids within 7 days prior to Day 0.
Patients who have undergone prior intraocular (non-laser) surgery in the study eye within 6 months prior to screening.

Locations

Lancaster, California, 93534
Lancaster, California, 93534

Tracking Information

NCT #
NCT02006888
Collaborators
Not Provided
Investigators
Study Director: howard franklin, md ICON Bioscience Inc