The Effect of Anti-CεmX on IgE Production
Last updated on April 2022Recruitment
- Recruitment Status
- Completed
Inclusion Criteria
- Clinical diagnosis of atopic dermatitis or chronic urticaria
- Male and female subjects aged ≥ 18 years
- Clinical diagnosis of atopic dermatitis or chronic urticaria
- Male and female subjects aged ≥ 18 years
Summary
- Conditions
- Atopic Dermatitis
- Type
- Observational
- Design
- Observational Model: Case-Only
- Time Perspective: Retrospective
Participation Requirements
- Age
- Between 18 years and 125 years
- Gender
- Both males and females
Description
This study will collect blood from patients of high serum IgE levels to investigate the function of h4b12, a humanized mAb specific for mIgE+ B cells, and compare the effects of h4B12, Omalizumab, and Rituxumab on the suppression of IgE production and the number of IgE-producing plasma cells. These ...
This study will collect blood from patients of high serum IgE levels to investigate the function of h4b12, a humanized mAb specific for mIgE+ B cells, and compare the effects of h4B12, Omalizumab, and Rituxumab on the suppression of IgE production and the number of IgE-producing plasma cells. These blood specimens will be collected from 50 patients of atopic dermatitis or urticaria with high serum IgE levels. Fountain Biopharma will carry out the following two in vitro assays to measure the efficacy of h4B12: IgE ELISA to determine the concentration of IgE. IgE ELISPOTto determine the number of IgE-producing plasma cells.
Inclusion Criteria
- Clinical diagnosis of atopic dermatitis or chronic urticaria
- Male and female subjects aged ≥ 18 years
- Clinical diagnosis of atopic dermatitis or chronic urticaria
- Male and female subjects aged ≥ 18 years
Tracking Information
- NCT #
- NCT01995747
- Collaborators
- Not Provided
- Investigators
- Principal Investigator: Chia-Yu Chu, M.D., Ph.D. Dept of Dermatology, NTUH
- Chia-Yu Chu, M.D., Ph.D. Dept of Dermatology, NTUH